The study was conducted in a tertiary care facility in Rawalpindi, Pakistan. The objective was establishment of a service delivery system in a tertiary care facility of Rawalpindi for screening, early diagnosis and prompt management of women with post natal depression. It also evaluated the effectiveness of the service and determined the frequency of Postnatal Depression cases presenting in the postnatal clinic of Rawalpindi General Hospital. This interventional study involved screening and confirmation of diagnosis for Postnatal depression of 908 mothers presenting in the postnatal clinic. The scales used were Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale. EPDS showed scores above cutoff of 10 for 318 (35%) mothers. When Hamilton scale was applied, 05 (1.57%) mothers had no confirmed diagnosis of Depression, however, all the remaining 313 mothers (98.42%) had Depression. The prevalence of the post natal depression was found to be 313 per 1000 or 31%. Statistically significant associations were observed on Chi Squared test, between PND and variables like mothers educational status, their working status, number of previous children, mode of last delivery, obstetrical complications during last pregnancy, age group, monthly family income, Effectiveness of the services rendered were evaluated by applying t-test by comparing the mean weekly turn over of PND patients over 35 wks study period and showed statistically significant difference in favor of interventional services with t-statistic of 16.263, p-value of 0.000.