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Remission of positive symptoms according to the “remission in Schizophrenia Working Group” criteria: A longitudinal study of cognitive functioning

Published online by Cambridge University Press:  15 April 2020

Y. Braw
Affiliation:
Department of Behavioral Sciences, Ariel University Center of Samaria, Ariel, Israel The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel
R. Sitman
Affiliation:
The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel
M. Cohen
Affiliation:
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
U. Berger
Affiliation:
Department of Psychology, and the Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
S. Lev-Ran
Affiliation:
The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
A. Segev
Affiliation:
The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Y. Bloch
Affiliation:
The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Y. Levkovitz*
Affiliation:
The Emotion-Cognition Research Center, Shalvata Mental Health Center (affiliated with Tel-Aviv University), Hod-Hasharon, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
*
*Corresponding author. Tel.: +9 729 747 8644; fax: +9 727 747 8643. E-mail address:ylevk@clalit.org.il (Y. Levkovitz).
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Abstract

Schizophrenia patients in positive symptomatic remission (PSR; n = 39) were assessed using a longitudinal research design. The patients were found to exhibit widespread cognitive impairments that were stable over the three-year follow-up period. The findings support a generalized and stable cognitive impairment profile among schizophrenia patients in partial symptomatic remission.

Type
Short Communication
Copyright
Copyright © European Psychiatric Association

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Footnotes

Abbreviations: CGI, Clinical Global Impression; ECT, Electro-convulsive therapy; GAF, General Assessment of Functioning; IRB, Institutional Review Board; PANSS, Positive and Negative Syndrome Schedule for Schizophrenia; RSWG, Remission in Schizophrenia Working Group; SANS, Scale for Assessment of Negative Symptoms; SCID, Structured Clinical Interview for DSM-IV; SCID-NP, Structured Clinical Interview for DSM-IV Non-patient; SOFAS, Social and Occupational Functioning Assessment Scale; PSR, Positive Symptomatic Remission; CANTAB, Cambridge Neuropsychological Test Automated Battery.

References

Andreasen, NC, Carpenter, WT Jr., Kane, JM, Lasser, RA, Marder, SR, Weinberger, DRRemission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry 2005;162(3):441449.CrossRefGoogle ScholarPubMed
Bonferroni, CE.Teoria statistica delle classi e calcolo delle probabilità. Pubblicazioni del R Istituto Superiore di Scienze Economiche e Commerciali di Firenze; 8:362 1936.Google Scholar
Buckley, PF, Harvey, PD, Bowie, CR, Loebel, AThe relationship between symptomatic remission and neuropsychological improvement in schizophrenia patients switched to treatment with ziprasidone. Schizophr Res 2007;94(1–3):99106.CrossRefGoogle ScholarPubMed
Buckley, PF, Miller, BJ, Lehrer, DS, Castle, DJPsychiatric comorbidities and schizophrenia. Schizophr Bull 2009;35(2):383402.CrossRefGoogle Scholar
Ceaser, AE, Goldberg, TE, Egan, MF, McMahon, RP, Weinberger, DR, Gold, JMSet-shifting ability and schizophrenia: a marker of clinical illness or an intermediate phenotype?. Biol Psychiatry 2008;64(9):782788.CrossRefGoogle ScholarPubMed
Cohen, JStatistical power analyses for the behavioural sciences. 2 Ed. New York: Academic Press; 1988.Google Scholar
Cohen, JA power primer. Psychol Bull 1992;112(1):155159.CrossRefGoogle ScholarPubMed
Collie, A, Maruff, P, Darby, DG, McStephen, MThe effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals. J Int Neuropsychol Soc 2003;9(3):419428.CrossRefGoogle ScholarPubMed
Crow, TJMolecular pathology of schizophrenia: more than one disease process?. Br Med J 1980;280(6207):6668.CrossRefGoogle ScholarPubMed
Davidson, L, Schmutte, T, Dinzeo, T, Andres-Hyman, RRemission and recovery in schizophrenia: practitioner and patient perspectives. Schizophr Bull 2008;34(1):58.CrossRefGoogle ScholarPubMed
Emsley, R, Chiliza, B, Asmal, L, Lehloenya, KThe concepts of remission and recovery in schizophrenia. Curr Opin Psychiatry 2011;24(2):114121.Google Scholar
Fornito, A, Yucel, M, Dean, B, Wood, SJ, Pantelis, CAnatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophr Bull 2009;35(5):973993.CrossRefGoogle ScholarPubMed
Goldberg, TE, Keefe, RS, Goldman, RS, Robinson, DG, Harvey, PDCircumstances under which practice does not make perfect: a review of the practice effect literature in schizophrenia and its relevance to clinical treatment studies. Neuropsychopharmacology 2010;35(5):10531062.CrossRefGoogle Scholar
Gorwood, P, Peuskens, JSetting new standards in schizophrenia outcomes: symptomatic remission 3 years before versus after the andreasen criteria. Eur Psychiatry 2012;27(3):170175.CrossRefGoogle ScholarPubMed
Harvey, PD, Bellack, ASToward a terminology for functional recovery in schizophrenia: is functional remission a viable concept?. Schizophr Bull 2009;35(2):300306.CrossRefGoogle Scholar
Heinrichs, RW, Zakzanis, KKNeurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12(3):426445.CrossRefGoogle Scholar
Joyce, EM, Hutton, SB, Mutsatsa, SH, Barnes, TRCognitive heterogeneity in first-episode schizophrenia. Br J Psychiatry 2005;187:516522.CrossRefGoogle ScholarPubMed
Kane, JMAn evidence-based strategy for remission in schizophrenia. J Clin Psychiatry 2008;69(Suppl. 3):2530.Google ScholarPubMed
Karow, A, Moritz, S, Lambert, M, Schottle, D, Naber, DRemitted but still impaired? Symptomatic versus functional remission in patients with schizophrenia. Eur Psychiatry 2011.Google ScholarPubMed
Kirkpatrick, B, Fenton, WS, Carpenter, W.T. Jr., Marder, SRThe NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull 2006;32(2):214219.CrossRefGoogle ScholarPubMed
Kurachi, MPathogenesis of schizophrenia: part I. Symptomatology, cognitive characteristics and brain morphology. Psychiatry Clin Neurosci 2003;57(1):38.CrossRefGoogle ScholarPubMed
Kurtz, MMNeurocognitive impairment across the lifespan in schizophrenia: an update. Schizophr Res 2005;74(1):1526.CrossRefGoogle ScholarPubMed
Lasser, RA, Bossie, CA, Gharabawi, GM, Kane, JMRemission in schizophrenia: results from a 1-year study of long-acting risperidone injection. Schizophr Res 2005;77(2–3)>:215227.CrossRefGoogle ScholarPubMed
Leung, WW, Bowie, CR, Harvey, PDFunctional implications of neuropsychological normality and symptom remission in older outpatients diagnosed with schizophrenia: a cross-sectional study. J Int Neuropsychol Soc 2008;14(3):479488.CrossRefGoogle ScholarPubMed
Levaux, MN, Potvin, S, Sepehry, AA, Sablier, J, Mendrek, A, Stip, EComputerized assessment of cognition in schizophrenia: promises and pitfalls of CANTAB. Eur Psychiatry 2007;22(2):104115.CrossRefGoogle ScholarPubMed
Lieberman, JAIs schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psychiatry 1999;46(6):729739.CrossRefGoogle ScholarPubMed
Matza, LS, Buchanan, R, Purdon, S, Brewster-Jordan, J, Zhao, Y, Revicki, DAMeasuring changes in functional status among patients with schizophrenia: the link with cognitive impairment. Schizophr Bull 2006;32(4):666678.CrossRefGoogle ScholarPubMed
Ojeda, N, Sanchez, P, Elizagarate, E, Yoller, AB, Ezcurra, J, Ramirez, I, et al.Course of cognitive symptoms in schizophrenia: a review of the literature. Actas Esp Psiquiatr 2007;35(4):263270.Google ScholarPubMed
Palmer, BW, Dawes, SE, Heaton, RKWhat do we know about neuropsychological aspects of schizophrenia?. Neuropsychol Rev 2009;19(3):365384.CrossRefGoogle ScholarPubMed
Peer, JE, Kupper, Z, Long, JD, Brekke, JS, Spaulding, WDIdentifying mechanisms of treatment effects and recovery in rehabilitation of schizophrenia: longitudinal analytic methods. Clin Psychol Rev 2007;27(6):696714.CrossRefGoogle ScholarPubMed
Rund, BRA review of longitudinal studies of cognitive functions in schizophrenia patients. Schizophr Bull 1998;24(3):425435.CrossRefGoogle ScholarPubMed
Salthouse, TA, Schroeder, DH, Ferrer, EEstimating retest effects in longitudinal assessments of cognitive functioning in adults between 18 and 60 years of age. Dev Psychol 2004;40(5):813822.CrossRefGoogle ScholarPubMed
San, L, Ciudad, A, Alvarez, E, Bobes, J, Gilaberte, ISymptomatic remission and social/vocational functioning in outpatients with schizophrenia: prevalence and associations in a cross-sectional study. Eur Psychiatry 2007;22(8):490498.CrossRefGoogle ScholarPubMed
Spitzer, RL, Williams, JB, Gibbon, MStructured clinical interview for DSM-III-R: non-patient version (SCID-NP). New York: New-York State Psychiatric Institute; 1989.Google Scholar
Spitzer, RL, Williams, JB, Gibbon, M, First, MBThe structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description. Arch Gen Psychiatry 1992;49(8):624629.CrossRefGoogle ScholarPubMed
Townsend, LA, Norman, RMCourse of cognitive functioning in first episode schizophrenia spectrum disorders. Expert Rev Neurother 2004;4(1):6168.CrossRefGoogle ScholarPubMed
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