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Rates of 1-year cognitive impairment in older adults who developed delirium due to a systemic infection

Published online by Cambridge University Press:  13 August 2021

A.R. Silva ,
A.L. Cardoso ,
I. Baldeiras ,
I. Santana  and
J. Cerejeira
A.R. Silva*
Affiliation:
University Of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
A.L. Cardoso
Affiliation:
University Of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
I. Baldeiras
Affiliation:
University Of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
I. Santana
Affiliation:
University Of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
J. Cerejeira
Affiliation:
University Of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
*
*Corresponding author.

Abstract

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Introduction

Delirium affects a significant proportion of hospitalized older patients with acute infections. There is growing evidence that delirium accelerates the cognitive decline at long term.

Objectives

We aimed to determine if delirium during hospitalization was independently associated with cognitive deterioration at one-year.

Methods

From a total of 22 patients (12 C, 4 Dem, 2 D, and 4 DD) delirium (D and DD groups) was associated with a worse score in MOCA of 3-points (p<.02) and 2.5-points (p<.03), respectively, at one year, follow up. Dementia patients without delirium had a decrease of 2-point (p=.04) while cognitively healthy patients had a decrease in 1.08 points (p=.05) (Graph1). MOCA and NPI scores during hospitalization correlated significantly with cognitive decline in the four groups (r=.658, p<.01 and r=.439, p=.02, respectively.)

Results

From a total of 22 patients (12 C, 4 Dem, 2 D and 4 DD) delirium (D and DD groups) was associated with a worse score in MOCA of 3-points (p<.02) and 2.5-points (p<.03), respectively, at one year follow up. Dementia patients without delirium had a of 2-point (p=.04) while cognitively healthy patients had a decrease in 1.08 points (p=.05) (Graph1). MOCA and NPI scores during hospitalization correlated significantly with cognitive decline in the four groups (r=.658, p<.01 and r=.439, p=.02, respectively.)

Conclusions

Individuals developing delirium while recovering from infection have higher rates of cognitive decline after one year, but the cognitive decline is also present to a lower extent for individuals with infections that did not develop delirium.

Disclosure

No significant relationships.

Keywords

deliriumcognitive impairmentHospitalizationdementia
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S137 - S138
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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