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PW01-155 - Seasonal Alterations Of Serotonin-1a Receptor Binding In The Healthy Human Brain

Published online by Cambridge University Press:  17 April 2020

C. Spindelegger
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
P. Stein
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
W. Wadsak
Affiliation:
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
M. Fink
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
M. Mitterhauser
Affiliation:
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
U. Moser
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
M. Savli
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
L.-K. Mien
Affiliation:
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
E. Akimova
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
A. Hahn
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
M. Willeit
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
K. Kletter
Affiliation:
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
S. Kasper
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria
R. Lanzenberger
Affiliation:
Department of Psychiatry and Psychotherapy, Vienna, Austria

Abstract

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Objectives

Serotonergic neurotransmission plays a key role in seasonal changes of mood and behaviour. Higher serotonin transporter availability in healthy human subjects in times of lesser light has been reported in recent studies. Furthermore, seasonal alterations of postsynaptic serotonin-1A receptors have been suggested by a recent animal study. Following that, this study aimed at identifying seasonal alterations of serotonin-1A receptor binding in the living human brain.

Methods

Thirty-six healthy, drug-naïve subjects were investigated using PET and the specific tracer [carbonyl-11C]WAY-100635. Regional serotonin-1A receptor binding (5-HT1A BPND) was related to the individual exposure to global radiation. Furthermore, the subjects were divided into two groups depending on individual exposure to global radiation, and the group differences in regional 5-HT1A BPND were determined.

Results

Correlation analysis controlled for age and gender revealed highly significant positive correlations between regional postsynaptic 5-HT1A BPND and global radiation accumulated for 5 days (r=.32 to .48, p=.030 to .002). Highly significant differences in 5-HT1A BPND binding between subjects with low compared to high exposure to global radiation were revealed (T=-2.63 to -3.77, p .013 to .001). 20% to 30% lower 5-HT1A BPND was found in the subject group exposed to lower amount of global radiation.

Conclusion

Seasonal factors such as exposure to global radiation influence postsynaptic serotonin-1A receptor binding in various brain regions in healthy human subjects. In combination with seasonal alterations in serotonin turnover and 5-HTT availability revealed in recent studies, our results provide an essential contribution of molecular mechanisms in seasonal changes of human serotonergic neurotransmission.

Type
Neuroimaging
Copyright
Copyright © European Psychiatric Association 2009
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