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Psychiatric disorder in young adults born very preterm: Role of family history

Published online by Cambridge University Press:  05 September 2008

M. Walshe ,
L. Rifkin ,
M. Rooney ,
E. Healy ,
C. Nosarti ,
J. Wyatt ,
D. Stahl ,
R.M. Murray  and
M. Allin
M. Walshe*
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
L. Rifkin
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
M. Rooney
Affiliation:
St. Michael's Unit, Mercy University Hospital, Grenville Place, Cork, Ireland
E. Healy
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
C. Nosarti
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
J. Wyatt
Affiliation:
Department of Paediatrics and Child Health, Rayne Building, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
D. Stahl
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
R.M. Murray
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
M. Allin
Affiliation:
NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK
*
*Corresponding author. Tel.: +44 20 7848 0057; fax: +44 20 7701 9044. E-mail address: m.walshe@iop.kcl.ac.uk (M. Walshe).
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Abstract

Objective

To investigate whether young adults born very preterm (VPT) (<33 weeks) are at increased risk for psychiatric illness in adulthood and whether a family history of psychiatric disorder further increases this risk.

Methods

We assessed 169 VPT and 101 term born individuals using the Clinical Interview Schedule – Revised.

Results

Young adults born VPT had an increased risk for psychiatric disorder compared to controls (OR = 3.1, 95% CI = 1.1–8.6, p = 0.03). Those born VPT who had a history of psychiatric disorder in a first-degree relative, had an increase in risk for psychiatric disorder compared to those born VPT without a family history (OR = 5.2, 95% CI = 1.8–14.9, p = 0.002).

Conclusion

Individuals born VPT are at increased risk of psychiatric illness in young adulthood compared to controls. In addition, a family history of psychiatric disorder in a first-degree relative may leave young adults born VPT particularly vulnerable to psychiatric illness.

Keywords

Preterm birthPsychiatric disorderYoung adultFamily history
Type
Case report
Information
European Psychiatry , Volume 23 , Issue 7 , October 2008 , pp. 527 - 531
Copyright
Copyright © Elsevier Masson SAS 2008

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