Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-06-25T04:10:52.088Z Has data issue: false hasContentIssue false
  • English
  • Français

Proton magnetic resonance spectroscopy (1H-MRS) of the thalamus in schizophrenia

Published online by Cambridge University Press:  16 April 2020

P Delamillieure ,
J.M Constans ,
J Fernandez ,
P Brazo  and
S Dollfus
P Delamillieure
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
J.M Constans
Affiliation:
Centre IRM, Centre Hospitalier et Universitaire, 14000Caen, France
J Fernandez
Affiliation:
Centre IRM, Centre Hospitalier et Universitaire, 14000Caen, France
P Brazo
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
S Dollfus*
Affiliation:
Groupe d’Imagerie Neurofonctionnelle UMR CNRS 6095/CEA/Université de Caen et Paris V et Centre Esquirol, Centre Hospitalier et Universitaire, 14000Caen, France
*
*Correspondence and reprints. Email address: dollfus-s@chu-caen.fr (S. Dollfus).
Get access

Extract

This study applied 1H-MRS in the thalamus of schizophrenic patients and healthy subjects.

There were no differences in the metabolite ratios (NAA/Cr, Cho/Cr or mI/Cr) between the two groups. Relationships were noted between NAA/Cr and age in patients with a trend toward this correlation in controls, suggesting an effect of age on the metabolism of the thalamus.

Keywords

agingN-acetyl-aspartateschizophreniaspectroscopythalamus
Type
Short Communication
Information
European Psychiatry , Volume 15 , Issue 8 , December 2000 , pp. 489 - 491
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, NCArndt, SSwayze, V.W.I.ICizadlo, TFlaum, MO’Leary, D et al. Thalamic abnormalities in schizophrenia visualized through schizophrenia: a proton magnetic resonance spectroscopic imaging study Biol Psychiatry 1998; 43: 641–648Google Scholar
Bertolino, ACallicott, JHElman, IMattay, VSTedeschi, GFrank, JA et al. Regionally specific neuronal pathology in untreated patients with schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging Am J Psychiatry 1996; 153: 1554–1563Google Scholar
Bertolino, ANawroz, SMattay, VSBarnett, ASDuyn, JHMoonen, C.T.W et al. Regionally specific pattern of neurochemical pathology in magnetic resonance image averaging Science 1994; 266: 294–298Google Scholar
Charles, HCLazeyras, FKrishnan, KRBoyko, OBPatterson, LJDoraiswamy, PM et al. Proton spectroscopy of human brain: effects of age and sex Prog Neuropsychopharmacol Biol Psychiatry 1994; 18: 9995–10004CrossRefGoogle ScholarPubMed
Deicken, RFJohnson, CEliaz, YSchuff, NReduced concentrations of thalamic N-acetyl-aspartate in male patients with schizophrenia Am J Psychiatry 2000; 157: 644–647CrossRefGoogle ScholarPubMed
Fukuzako, HHashiguchi, TSakamoto, YOkamura, HDoi, WTakenouchi, K et al. Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects Psychiatry Clin Neurosci 1997; 51: 261–263CrossRefGoogle ScholarPubMed
Hazlett, EABuchsbaum, MSByne, WWei, TCSpiegel-Cohen, JGeneve, C et al. Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum Am J Psychiatry 1999; 156: 1190–1199Google ScholarPubMed
Lim, KOAdalsteinsson, ESpielman, DSullivan, EVRosenbloom, MJProton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia Arch Gen Psychiatry 1998; 55: 346–352CrossRefGoogle Scholar
Omori, MPearce, JKomoroski, RAGriffin, STMrak, REHusain, MM et al. In vitro 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia Biol Psychiatry 1997; 42: 359–366CrossRefGoogle ScholarPubMed
Pakkenberg, BPronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics Arch Gen Psychiatry 1990; 47: 1023–1028CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.