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Prevalence of Toxoplasma gondii IgG Antibodies in Psychiatric Patients from Western Romania

Published online by Cambridge University Press:  27 August 2024

S. Grada ,
M. A. Lupu ,
D. A. Oatis ,
A. G. Mihu  and
T. R. Olariu
S. Grada*
Affiliation:
1County Emergency Hospital Arad, Arad 2Discipline of Parasitology 3Center for Diagnosis and Study of Parasitic Diseases, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
M. A. Lupu
Affiliation:
2Discipline of Parasitology 3Center for Diagnosis and Study of Parasitic Diseases, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
D. A. Oatis
Affiliation:
1County Emergency Hospital Arad, Arad 3Center for Diagnosis and Study of Parasitic Diseases, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
A. G. Mihu
Affiliation:
2Discipline of Parasitology 3Center for Diagnosis and Study of Parasitic Diseases, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
T. R. Olariu
Affiliation:
2Discipline of Parasitology 3Center for Diagnosis and Study of Parasitic Diseases, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
*
*Corresponding author.

Abstract

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Introduction

Toxoplasma gondii, a ubiquitous protozoan parasite, has been previously associated with psychiatric disorders.

Objectives

To assess the prevalence of IgG antibodies against T. gondii in psychiatric patients from Western Romania.

Methods

We included 464 psychiatric patients admitted to the Psychiatric Clinic, County Emergency Hospital of Arad, Western Romania. Clinical evaluation and laboratory tests were conducted in these patients, including serological tests to determine the presence of T. gondii IgG antibodies.

Results

Of the 464 psychiatric patients, 258 (55.5%) were residing in rural areas and 245 (52.7%) were female. T. gondii IgG antibodies were demonstrated in 325 (70.04%) of 464 study participants and the seroprevalence tended to increase with age.

A significant higher T. gondii IgG seroprevalence was found in psychiatric patients aged between 40 to 59 years (p<0.001) and in patients aged ≥60 years (p=0.001) compared to patients aged 19 to 39 years. A higher T. gondii IgG seroprevalence was determined in psychiatric patients residing in rural areas compared to those residing in urban areas (p=0.04). T. gondii IgG seroprevalence was higher in females compared to males (p=0.04).

Assessment of seroprevalence by diagnostic revealed that T. gondii IgG antibodies were identified in 23 (85.19%) of 27 patients with delusional disorders, 24 (82.76%) of 29 with dementia, 51 (70.83%) of 72 with organic disorders, 75 (70.75%) of 106 with schizophrenia, 81 (70.43%) of 115 patients with depression, 17 (62.96%) of 27 with bipolar disorders, 27 (58.7%) of 46 with mood disorders and 7 (53.85%) of 13 with impulsive-control disorders.

Conclusions

The presence of T. gondii antibodies was demonstrated in a significant number of patients who attended the Psychiatric Clinic in Arad County, Western Romania. Results of this study suggest that T. gondii may be associated with several psychiatric disorders.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S344
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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