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Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics

Published online by Cambridge University Press:  16 April 2020

U. Müller ,
K. Werheid ,
E. Hammerstein ,
S. Jungmann  and
T. Becker
U. Müller*
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany Departments of Psychiatry and Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
K. Werheid
Affiliation:
Department of Cognitive Neurology, University of Leipzig, Leipzig, Germany Department of Psychology, Humboldt University Berlin, Berlin, Germany
E. Hammerstein
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
S. Jungmann
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany
T. Becker
Affiliation:
Department of Psychiatry, University of Leipzig, Leipzig, Germany Department of Psychiatry II, University of Ulm, Günzburg, Germany
*
*Corresponding author. E-mail address: um207@cam.ac.uk
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Abstract

Forty-three patients with schizophrenia were investigated with a short neurocognitive screening battery focussing on working memory and executive functions. As compared to healthy controls, patients showed impairments in the modified card sorting test, in verbal fluency and all span tasks with exception of digit span forward. Patients who were treated with atypicals showed better performance in the digit ordering test (manipulation task) when compared to a group of patients who received conventional antipsychotics; this difference was not due to disease severity, age or education. Manipulation tasks might be useful for neurocognitive follow-up and intervention studies.

Keywords

Antipsychotic agentsExecutive functionsDigit ordering testSchizophreniaWorking memory
Type
Short communication
Information
European Psychiatry , Volume 20 , Issue 1 , January 2005 , pp. 70 - 73
Copyright
Copyright © Elsevier SAS 2005

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