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Platelet counts in depressed patients treated with amitriptyline or paroxetine

Published online by Cambridge University Press:  16 April 2020

F. Lederbogen ,
E. Hörer ,
R. Hellweg ,
I. Heuser  and
M. Deuschle
F. Lederbogen*
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
E. Hörer
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
R. Hellweg
Affiliation:
Department of Psychiatry, Free University, Berlin, Germany
I. Heuser
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany Department of Psychiatry, Free University, Berlin, Germany
M. Deuschle
Affiliation:
Central Institute of Mental Health, J5, 68159Mannheim, Germany
*
*E-mail address: lederbog@as200.zi-mannheim.de
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Abstract

Objective

To assess whether therapy with two widely used antidepressants influences platelet counts.

Subjects and methods

In 90 patients hospitalized for treatment of a major depressive episode according to DSM-IV, platelet counts were performed after a 6 d antidepressant-free run-in period and again after 35 d of active standardized treatment with amitriptyline (n = 40) or paroxetine (n = 50).

Results

There was a trend for platelet counts to increase during treatment with amitriptyline (from 245.5 ± 68.6 to 256.8 ± 69 cells × 109 L-1, P < 0.06); no change was observed during treatment with paroxetine (from 232.6 ± 58.3 to 234.6 ± 68.9 cells × 109 L-1, n.s).

Conclusions

Treatment with amitriptyline tends to be associated with elevated platelet counts. The cause for this increase is not known, but may be relevant in terms of patients’ long-term thromboembolic risk.

Keywords

Platelet countDepressionAntidepressant
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 2 , March 2003 , pp. 89 - 91
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2002

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References

Ariyo, AA, Haan, M, Tangen, CM, Rutledge, JC, Cushman, M, Dobs, A, et al. Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Circulation 2000;102: 1773–9.CrossRefGoogle ScholarPubMed
Berk, M, Jacobson, BF, Hurly, E.Fluoxetine and hemostatic function: a pilot study. J Clin Psychiatry 1995;56:14–6.Google ScholarPubMed
Canoso, R.Effects of neuroleptics on the immune system. In: Kane, JM, Lieberman, JA, editors. Adverse effects of psychotropic drugs. NewYork: The Guilford Press; 1992. p. 395–487.Google Scholar
Deuschle, M, Hamann, B, Meichel, C, Krumm, B, Lederbogen, F, Kniest, A, et al. Antidepressive treatment with amitriptyline and paroxetine: effects upon saliva cortisol concentrations. J Clin Psychopharmacol (in press).Google Scholar
Glassman, A, Shapiro, PA.Depression and the course of coronary artery disease. Am J Psychiatry 1998;155:4–11.CrossRefGoogle ScholarPubMed
Heuser, I.The hypothalamic-pituitary-adrenal system in depression. Pharmacopsychiatry 1998;31:10–3.CrossRefGoogle ScholarPubMed
Hoeksema, T, Goekoop, JG, Van Kempen, GMJ.Effects of fluvoxamine on whole-blood serotonin and platelet number. J Clin Psychopharmacol 1993;13:75–6.CrossRefGoogle ScholarPubMed
Krivy, J, Wiener, J.Sertraline and platelet counts in idiopathic thrombocytopenia purpura. Lancet 1995;345:132.CrossRefGoogle ScholarPubMed
Lake, MB, Birmaher, B,Wassick, S, Mathos, K,Yelovich, AK.Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence. J Child Adolesc Psychopharmacol 2000;10:35–8.CrossRefGoogle ScholarPubMed
Lederbogen, F, Gilles, M, Maras, A, Hamann, B, Colla, M, Heuser, I, et al. Increased platelet aggregability in major depression? Psychiatry Res 2001;102:255–61.CrossRefGoogle ScholarPubMed
Maes, M, Scharpe, S, Bosmans, E, Vandewoude, M, Suy, E, Uyttenbroeck, W, et al. Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness. Prog Neuropsychopharmacol Biol Psychiatry 1992;16:501–15.CrossRefGoogle ScholarPubMed
Markovitz, JH, Matthews, KA, Kiss, J, Smitherman, TC.Effects of hostility on platelet reactivity to psychological stress in coronary heart disease patients and in healthy controls. Psychosom Med 1996;58: 143–9.CrossRefGoogle ScholarPubMed
Musselman, DL, Tomer, A, Manatunga, AK, Knight, BT, Porter, MR, Kasey, S, et al. Exaggerated platelet reactivity in major depression. Am J Psychiatry 1996;153:1313–7.Google ScholarPubMed
Musselman, DL, Marzec, UM, Manatunga, A, Penna, S, Reemsnyder, A, Knight, BT, et al. Platelet reactivity in depressed patients treated with paroxetine: preliminary findings. Arch Gen Psychiatry 2000;57: 875–82.CrossRefGoogle ScholarPubMed
Seidel, A, Arolt, V, Hunstiger, M, Rink, L, Behnisch, A, Kirchner, H.Major depressive disorder is associated with elevated monocyte counts. Acta Psychiatr Scand 1996;94:198–204.Google ScholarPubMed
Taniguchi, S, Hamada, T.Photosensitivity and thrombocytopenia due to amitriptyline. Am J Hematol 1996;53:49–50.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Thaulow, E, Erikssen, J, Sandvik, L, Stormorken, H, Cohn, PF.Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991;84:613–7.CrossRefGoogle ScholarPubMed
Van Kempen, GMJ, Zitman, FG, Linssen, ACG, Edelbrock, PM.Biochemical measures in patients with a somatoform pain disorder, before, during and after treatment with amitriptyline with or without flupentixol. Pain 1991;47:25–30.Google Scholar
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