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Plasma concentrations of IL-8, IFN-γ and IL-1β in schizophrenia patients with subgroup analysis of first episode drug naïve patients

Published online by Cambridge University Press:  27 August 2024

M. Markovic ,
M. Stasevic ,
M. Stojkovic ,
M. Velimirović Bogosavljević ,
T. Stojkovic ,
M. Zivkovic ,
I. Stasevic Karlicic ,
T. Nikolic ,
S. Totic Poznanovic  and
N. Petronijevic
M. Markovic*
Affiliation:
1Clinic for Mental Disorders “Dr Laza Lazarević”, Belgrade, Serbia, Belgrade
M. Stasevic
Affiliation:
1Clinic for Mental Disorders “Dr Laza Lazarević”, Belgrade, Serbia, Belgrade
M. Stojkovic
Affiliation:
2Clinic for neurology, University Clinical Centre of Nis, Nis
M. Velimirović Bogosavljević
Affiliation:
3Institute for medical and clinical biochemistry 4Faculty of Medicine, University of Belgrade, Belgrade
T. Stojkovic
Affiliation:
3Institute for medical and clinical biochemistry 4Faculty of Medicine, University of Belgrade, Belgrade
M. Zivkovic
Affiliation:
3Institute for medical and clinical biochemistry
I. Stasevic Karlicic
Affiliation:
1Clinic for Mental Disorders “Dr Laza Lazarević”, Belgrade, Serbia, Belgrade 5Faculty of Medicine, University of Priština – Kosovska Mitrovica, Kosovska Mitrovica
T. Nikolic
Affiliation:
3Institute for medical and clinical biochemistry 4Faculty of Medicine, University of Belgrade, Belgrade
S. Totic Poznanovic
Affiliation:
4Faculty of Medicine, University of Belgrade, Belgrade 6Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia
N. Petronijevic
Affiliation:
3Institute for medical and clinical biochemistry 4Faculty of Medicine, University of Belgrade, Belgrade
*
*Corresponding author.

Abstract

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Introduction

Increased plasma concentrations of proinflammatory cytokines are found in chronic schizophrenia patients, patients with first episode and in individuals with high risk for psychosis. The most replicated findings are increased concentrations of IL-6, TNF-α and IL-1β through different phases of the disorder while the results for two important proinflammatory cytokines IL8 and IFN-γ were not consistent.

Objectives

Primary objective of this study was to assess differences in concentrations of IL-8, IFN-γ and IL-1β between schizophrenia patients and healthy controls, Secondary objective was to explore differences in first episode drug naïve patients.

Methods

We measured plasma concentrations of IL-8, IFN-γ and IL-1β in 64 healthy controls and 64 schizophrenia patients during acute exacerbation and remission phase. 25% were drug naive first episode schizophrenia patients. The patients were matched by age, sex and body mass index and exclusion criteria included obesity class 2 or higher, any concomitant organic mental or neurological disorder, acute or chronic inflammatory disease, and use of immunomodulatory drugs or psychoactive substances.

Results

Levels of IL-8 were significantly lower in patients with schizophrenia in acute phase and remission compared to healthy controls (p=0,009 for acute phase and p=0,020 for remission). There was no significant difference in the levels of INF-γ and IL-β between schizophrenia in acute phase and remission and healthy controls (p>0,05). In schizophrenia patients there was no difference in the levels of INF-γ, IL-β and IL-8 between acute phase, remission and healthy controls (p>0,05). There was no difference in plasma levels of IL-8, IFN-γ and IL-1β between first episode drug naïve and previously treated schizophrenia patients.

Conclusions

Our research did not find disturbance of plasma levels of IFN-γ and IL-1β in schizophrenia patients, although the increase of IL-1β was the most replicated finding up to date. Interestingly and contrary to expected the finding of significantly decreased levels of IL-8 in schizophrenia patients requires further research since IL-8 plays a vital role in the inflammatory pathway and may be implicated in cognitive dysfunction.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S278
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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