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Physical Health in Early and Late Stages of Bipolar Disorder

Published online by Cambridge University Press:  23 March 2020

M.P. García-Portilla ,
L. de la Fuente-Tomás ,
L. García-Álvarez ,
P. Sierra ,
B. Arranz ,
M. Sánchez  and
G. Safont
M.P. García-Portilla*
Affiliation:
University of Oviedo, Psychiatrist, Oviedo, Spain
L. de la Fuente-Tomás
Affiliation:
University of Oviedo, Psychiatrist, Oviedo, Spain
L. García-Álvarez
Affiliation:
CIBERSAM, Psychiatrist, Oviedo, Spain
P. Sierra
Affiliation:
Hospital La Fe, Psychiatrist, Valencia, Spain
B. Arranz
Affiliation:
Fundación San Juan de Dios, Psychiatrist, Barcelona, Spain
M. Sánchez
Affiliation:
Hospital Mutua de Terrassa, Psychiatrist, Barcelona, Spain
G. Safont
Affiliation:
Hospital Mutua de Terrassa, Psychiatrist, Barcelona, Spain
*
⁎Corresponding author.

Abstract

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Introduction

Bipolar disorder (BD) is related to high prevalence of somatic comorbidities, health care costs, and premature mortality [1]. Some evidence supports the view of BD as chronic, progressive and multisystem disorder in which not only mental system, but also somatic systems are involved [2].

Aim

To investigate differences in physical health in patients with bipolar disorder at different stages (early vs. late) of the disease.

Methods

Cross-sectional, naturalistic, multicenter study. Sample: 110 outpatients with BD [68 early stage (diagnosed at least 5 years earlier) and 42 late stage (at least 20 years earlier)]. Assessment: demographic and clinical variables; psychopathology: HDRS, YMRS and CGI; biological information: anthropometric, vital signs and lab results.

Results

Early stage group: mean age 40.1 (11.9), 66.2% females and CGI = 3.6 (1.4). Late stage group: mean age 55.8 (8.2), 69.0% females and CGI = 4.0 (1.4). Patients in early stage have significantly higher levels of glucose (t = −4.007, P < 0.001), urea (t = −2.724, P = 0.008), creatinine (F = 0.560, P = 0.022), triglycerides (t = −3.501, P = 0.001), Fe (t = 2.871, P = 0.005) and insulin (t = −3.223, P = 0.002). Moreover, they have higher Body Max Index (BMI) (t = −3.728, P < 0.000), abdominal circumference (t = −4.040, P < 0.000) and greater number of somatic comorbidities (t = −2.101, P = 0.041).

Conclusions

– patients with bipolar disorders in late stages have worse physical health than those in early stage.

– these results could be an indication that bipolar disorder might better viewed as a multisystem disorder.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Anxiety disorders and somatoform disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s113
Copyright
Copyright © European Psychiatric Association 2017

References

Kleine-Budde, K., et al.Cost of illness for bipolar disorder: a systematic review of the economic burden. Bipolar Disord 1642014 33735310.1111/bdi.12165CrossRefGoogle ScholarPubMed
Leboyer, M., Soreca, I., Scott, J., et al.Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord 14112012 11010.1016/j.jad.2011.12.049CrossRefGoogle ScholarPubMed
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