Skip to main content Accessibility help
×
Home

P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory

  • A.R. Dores (a1) (a2), F. Barbosa (a3), I. Almeida (a4), S. Guerreiro (a3) (a4), B.M. Rocha (a5), I.P. Carvalho (a5), A.J. Marques (a2), L.D. Sousa (a1) and A. Castro-Caldas (a6) (a7)...

Abstract

Introduction

Working memory (WM) is a cognitive process that refers to storing information in a temporary system that allows monitoring and handling this information.

Objectives

To propose and validate a new fMRI paradigm to study WM and its neuroanatomical substrates, using a language-free adaptation of the 2-back working memory task in order to avoid cultural and educational bias.

Aims

To test the hypothesis that the proposed paradigm would produce an increase of the BOLD signal in specialized areas for spatial WM (Superior Frontal Sulcus) and areas for monitoring and handling this information (Dorsolateral Prefrontal Cortex) in healthy participants. We also expected a significantly higher behavioral performance in this group than in subjects with suspected WM impairment due to acquired brain injury.

Methods

10 neurologically healthy participants and 11 ABI participants performed the task in a block design experiment with four runs. These observed a 9-square matrix with one of the squares painted black and pressed a button each time the black square was the same as the one two trials back. We analyzed behavioral performance and brain activation in repeated trials.

Results

Higher BOLD activation of brain regions was associated with the performance of the WM task in the healthy group, as well as better behavioral performance. We also present behavior results of both groups, so these data can be compared to other clinical groups with suspected WM deficits.

Conclusions

This task may be used as a research methodology for behavioral and neuroimaging studies of visual WM in block-design paradigms.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory
      Available formats
      ×

Copyright

P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory

  • A.R. Dores (a1) (a2), F. Barbosa (a3), I. Almeida (a4), S. Guerreiro (a3) (a4), B.M. Rocha (a5), I.P. Carvalho (a5), A.J. Marques (a2), L.D. Sousa (a1) and A. Castro-Caldas (a6) (a7)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

P-784 - A new Fmri Paradigm to Study Behavioral and Neural Bases of Visual Working Memory

  • A.R. Dores (a1) (a2), F. Barbosa (a3), I. Almeida (a4), S. Guerreiro (a3) (a4), B.M. Rocha (a5), I.P. Carvalho (a5), A.J. Marques (a2), L.D. Sousa (a1) and A. Castro-Caldas (a6) (a7)...
Submit a response

Comments

No Comments have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *