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P-707 - Population Distribution of the Serotonin Transporter Gene Polymorphisms

Published online by Cambridge University Press:  15 April 2020

H. Kuzelova
Affiliation:
Institute of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University, Prague, Czech Republic
N. Bila
Affiliation:
Institute of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University, Prague, Czech Republic
M. Macek
Affiliation:
Institute of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University, Prague, Czech Republic
I. Zukov
Affiliation:
Department of Psychiatry, 1st Faculty of Medicine Charles University, Prague, Czech Republic
R. Ptacek
Affiliation:
Department of Psychiatry, 1st Faculty of Medicine Charles University, Prague, Czech Republic

Abstract

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Introduction:

Serotonin transporter 5-HTT plays an important role in serotogenic transmisssion. Three polymorphisms, an insertion/deletion and SNP in the promoter region and a variable nucleotide tandem repeat (VNTR) in intron 2, influence expression of the 5-HTT gene. These polymorphisms can contribute to the etiology of many psychiatric disorders.

Associations between a functional variant in the serotonin transporter anxiety-related personality traits were found, as well as the risk of developing depression, alcoholism or suicidal behavior.

Aims:

The aim of the study was to found possible differences in distribution of variants in three age groups of population.

Methods:

We examined three polymorphisms at the serotonin transporter protein locus (SLC6A4) in free specific and representative cohorts drawn from the Czech population. These cohorts were stratified according to their age: group A - randomly selected elderly individuals (over 75 years of age), group B young adults in reproductive age (age ranging between 19–45 years) and c) group C - newborns, all with balanced gender representation.

Results and conclusions:

Analysis revealed that elderly individuals were statistically more likely than to carry two copies of the L allele of the lenth polymorphism. This may be due to the protective character of L allele, which is associated with lower susceptibility to bipolar affective disorder, depression, alcohol dependence and neuroticism and can be associated with good mental health and length of living.

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Abstract
Copyright
Copyright © European Psychiatric Association 2012
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