Hostname: page-component-76fb5796d-zzh7m Total loading time: 0 Render date: 2024-04-25T12:17:25.078Z Has data issue: false hasContentIssue false
  • English
  • Français

P300 event-related potential and serotonin-1A activity in depression

Published online by Cambridge University Press:  16 April 2020

M Hansenne  and
M Ansseau
M Hansenne
Affiliation:
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium
M Ansseau
Affiliation:
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium
Get access

Summary

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

Keywords

depressionflesinoxan testP300serotonin-1A
Type
Original Articles
Information
European Psychiatry , Volume 14 , Issue 3 , June 1999 , pp. 143 - 147
Copyright
Copyright © European Psychiatric Association 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Donchin, E, Coles, MHGIs the P300 component a manifestation of context updating?. Behav Brain Sci 1988 ; 11 : 357–374.CrossRefGoogle Scholar
Picton, TWThe P300 wave of the human event-related potential. J Clin Neurophysiol 1992 ; 9 : 456–479.CrossRefGoogle ScholarPubMed
Verleger, REvent-related potentials and cognition: a critique of the context updating hypothesis and an alternative interpretation of P3 Behav Brain Sci 1988 ; 11 : 343–356.CrossRefGoogle Scholar
Johnson, RA triarchic model of P300 amplitude Psychophysiology 1986 ; 23 : 367–384.CrossRefGoogle ScholarPubMed
Sommer, W, Matt, JAwareness of P300-related cognitive processes: a signal detection approach Psychophysiology 1990 ; 27 : 575–585.CrossRefGoogle ScholarPubMed
McCarthy, G, Donchin, EA metric for thought: a comparison of P300 latency and reaction time Science 1981 ; 211 : 77–80.CrossRefGoogle ScholarPubMed
Smulders, FTY, Kok, A, Kenemans, JD, Bashore, TRThe temporal selectivity of additive factor effects on the reaction process revealed in ERP component latencies Acta Psychol 1995 ; 90 : 97–109.10.1016/0001-6918(95)00032-PCrossRefGoogle ScholarPubMed
Kutas, M, McCarthy, G, Donchin, EAugmenting mental chronometry: the P300 as a measure of stimulus evaluation time Science 1977 ; 197 : 792–795.CrossRefGoogle ScholarPubMed
Diner, CB, Holcomb, PJ, Dykman, RAP300 in major depressive disorder Psychiatry Res 1985 ; 15 : 175–184.CrossRefGoogle ScholarPubMed
Muir, WJ, St Clair, DM, Blackwood, DHRLong-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder. Psychol M 1991 ; 21 : 867–879.CrossRefGoogle ScholarPubMed
Giedke, H, Bolz, J, Heimann, HEvoked potentials, expectancy wave and skin resistance in depressed patients and healthy controls Pharmacopsychiatry 1980 ; 13 : 91–101.10.1055/s-2007-1019618CrossRefGoogle ScholarPubMed
Plooij-Van, GEvoked potential correlates of information processing and habituation in depressive illness Ann N Y Acad Sci 1984 ; 425 : 609–617.Google Scholar
Gangadhar, BN, Ancy, J, Janakiramaiah, N, Umapathy, CP300 amplitude in non-bipolar, melancholic depression J Affect Disord 1993 ; 28 : 57–60.CrossRefGoogle ScholarPubMed
El, , Massioui, F, Lesèvre, NAttention impairment and psychomotor retardation in depressed patients: an event-related study Electroencephalogr Clin Neurophysiol 1988 ; 70 : 46–55.Google Scholar
Have, G, Kolbeinson, H, Pétursson, HDementia and depression in old age: psychophysiological aspects Acta Psychiatr Scand 1991 ; 83 : 329–333.CrossRefGoogle ScholarPubMed
Bruder, GE, Towey, JP, Stewart, JW, Friedman, D, Tenke, C, Quitkin, FMEvent-related potentials in depression: influence of task, stimulus hemifield and clinical features on P3 latency Biol Psychiatry 1991 ; 30 : 233–246.CrossRefGoogle ScholarPubMed
Gordon, E, Kraiuhin, C, Harris, A, Meares, R, Howson, AThe differential diagnosis of dementia using P300 latency Biol Psychiatry 1986 ; 21 : 1123–1132.10.1016/0006-3223(86)90220-9CrossRefGoogle ScholarPubMed
Patterson, JV, Mikaleski, HJ, Starr, ALatency variability of the components of auditory event related potentials to infrequent stimuli in aging, Alzheimer type dementia and depression Electroencephalogr Clin Neurophysiol 1988 ; 71 : 450–460.CrossRefGoogle ScholarPubMed
Santosh, PJ, Malhotra, S, Raghunathan, M, Mehra, YNA study of P300 in melancholic depression Correlation with psychotic features Biol Psychiatry 1994 ; 35 : 474–479.CrossRefGoogle ScholarPubMed
Pierson, A, Partiot, A, Ammar, S, Dodin, V, Loas, G, Jouvent, RERP differences between anxious-impulsive and blunted-affect depressive inpatients In: Ansseau, M, von Frenckell, R, Frank, Geds. Biological markers of depression: state of the art Amsterdam: Elsevier 1991 121–129.Google Scholar
Pierson, A, Ragot, R, Martinerie, J, Partiot, A, Renault, B, Jouvent, RHeterogeneity of information-processing alterations according to dimensions of depression: an event-related potentials study Biol Psychiatry 1996 ; 40 : 98–115.CrossRefGoogle Scholar
Hansenne, M, Pitchot, W, Gonzalez-Moreno, A, Gonzalez-Torrecilas, J, Mirel, J, Ansseau, MPsychophysiological correlates of suicidal behavior in depression A preliminary study Neuropsychobiology 1994 ; 30 : 1–3.CrossRefGoogle ScholarPubMed
Hansenne, M, Pitchot, W, Gonzalez-Moreno, A, Urcelay-Zaldua, I, Ansseau, MSuicidal behavior in depressive disorder: an event-related potential study Biol Psychiatry 40 1996 116–122.CrossRefGoogle Scholar
Hammond, EJ, Meador, KJ, Aung-Din, R, Wilder, BKRole of the cholinergic system in the generation of human cognitive evoked potentials Neurology 1987 ; 37 : 346–350.10.1212/WNL.37.2.346CrossRefGoogle Scholar
Meador, KJCholinergic, serotonergic, and gabaergic effects on the ERP In: Karmos, G, Molnár, MCsépe, VCzigler, I, Desmedt, JE eds. Perspectives of event-related potentials research Electroencephalogr Clin Neurophysiol Suppl 44 1995 Amsterdam: Elsevier 151–155.Google Scholar
Meador, KJ, Loring, DW, Davis, HC, Setli, KD, Patel, BR, Adams, RJCholinergic and serotonergic effects on P3 potential and recent memory J Clin Exp Neuropsychol 1989 ; 11 : 252–260.CrossRefGoogle ScholarPubMed
Jonkman, LM, Kemmer, C, Vertaben, MN, Koelega, HS, Camfferman, G, van der Gaag, RJEffects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks Biol Psychiatry 1997 ; 41 : 690–702.CrossRefGoogle ScholarPubMed
Swick, D, Pineda, A, Foote, SLEffects of systematic clonidine on auditory event-related potentials in squired monkeys Brain Res Bull 1994 ; 33 : 79–86.CrossRefGoogle Scholar
Semlitsch, HV, Anderer, P, Saletu, BAcute effects of the anxiolytics suriclone and alprazolam on cognitive processing utilizing topographic mapping of event-related brain potentials (P300 in healthy subjects) Eur J Clin Pharmacol 1995 ; 49 : 183–191.CrossRefGoogle Scholar
Hansenne, M, Pitchot, W, Gonzalez-Moreno, A, Papart, P, Timsit-Berthier, M, Ansseau, MCatecholaminergic function and P300 amplitude in major depressive disorder (P300 and catecholamines) Electroencephalogr Clin Neurophysiol 1995 ; 96 : 194–196.CrossRefGoogle Scholar
Pritchard, WS, Raz, N, August, GJNo effect of chronic fenfluramine on the P300 component of the event-related potential Int J Neurosci 1986 ; 35 : 105–110.CrossRefGoogle Scholar
Unrug, A, VanLuijtelaar, EL, Coles, MG, Coenen, AMEvent-related potentials in a passive and active auditory condition: effects of diazepam and buspirone on slow wave positivity Biol Psychol 1997 ; 46 : 101–111.CrossRefGoogle Scholar
Ito, J, Yamoa, S, Fukuda, H, Mimori, Y, Nakamura, SThe P300 event-related potentials in dementia of the Alzheimer type Correlations between P300 and monoamine metabolites Electroencephalogr Clin Neurophysiol 1990 ; 77 : 174–178.CrossRefGoogle ScholarPubMed
Meador, KJ, Loring, DW, Hendrix, N, Nichols, ME, Oberzan, R, Moore, EESynergistic anticholinergic and antiserotonergic effects in human J Clin Exp Neuropsychol 1995 ; 17 : 611–621.CrossRefGoogle Scholar
Hansenne, M, Pitchot, W, Papart, P, Ansseau, MSerotonergic modulation of the P300 event-related brain potential Hum Psychopharmacol 1998 ; 13 : 239–343.10.1002/(SICI)1099-1077(199806)13:4<239::AID-HUP986>3.0.CO;2-V3.0.CO;2-V>CrossRefGoogle Scholar
American Psychiatric Association Diagnostic and statistical manual of mental disorders, DSM-IV, fourth edition Washington, DCAmerican Psychiatric Association 1994Google Scholar
Hamilton, MA rating scale of depression. J Neurol Neurosurg Psychiatry 1960 ; 23 : 56–62.CrossRefGoogle Scholar
Raine, A, Venables, PHEnhanced P3 evoked potentials and longer recovery times in psychopaths. Psychophysiology 1988 ; 25 : 30–38.CrossRefGoogle ScholarPubMed
New, AS, Tresman, RL, Mitropoulou, V, Benishay, DS, Coccaro, EF, Silverman, JSerotonin function and self-injurious behavior in personality disorder patients.Psychiatry Res 1997 ; 69 : 17–26.CrossRefGoogle ScholarPubMed
Coccaro, E, Siever, LS, Klar, HM, Maurer, G, Cochran, K, Cooper, TBSerotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 1989 ; 46 : 587–599.CrossRefGoogle ScholarPubMed
Coccaro, EF, Gabriel, S, Siever, LJBuspirone challenge: Preliminary evidence for a role for central 5-HT1A receptor function in impulsive aggressive behavior in human. Psychopharmacol Bull 1990 ; 26 : 393–405.Google Scholar
Hansenne, M, Pitchot, W, Gonzalez-Moreno, A, Reggers, J, Machurot, PY, Ansseau, MHarm avoidance of the tridimensional personality questionnaire and serotonin-1A activity in depressed patients. Biol Psychiatry 1997 ; 42 : 959–961.CrossRefGoogle ScholarPubMed
Cassel, JC, Jeltsch, HSerotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 1995 ; 69 : 1–41.CrossRefGoogle ScholarPubMed
Harder, JA, Maclean, CJ, Alder, JT, Francis, PT, Ridley, RMThe 5-HT1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology 1996 ; 127 : 245–254.Google ScholarPubMed
Buhot, MCSerotonin receptors in cognitive behaviors. Curr Opin Neurobiol 1997 ; 7 : 243–254.10.1016/S0959-4388(97)80013-XCrossRefGoogle ScholarPubMed
Polich, JP300 in the evaluation of aging and dementia. In: Brunia, CHMMulder, GVertaben, MNeds. Event-related brain research Electroencephalogr Clin Neurophysiol Suppl 42 Amsterdam: Elsevier 1991 304–323.Google Scholar
Hasbroucq, T, Rihet, P, Blin, O, Possamai, CASerotonin and human information processing: fluvoxamine can improve reaction time performance. Neurosci Lett 1997 ; 229 : 204–208.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.