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P-199 - Panic-Agoraphobic Spectrum Symptoms are Associated With Impulsivity in Bipolar Disorder

Published online by Cambridge University Press:  15 April 2020

M. Preve
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Mula
Affiliation:
Department of Clinical & Experimental Medicine, Amedeo Avogadro University, Novara, Italy
S. Calugi
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
L. Lari
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
A. Cardini
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
L. Di Paolo
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Abelli
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
C. Gesi
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Muti
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
S. Pini
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa
M. Mauri
Affiliation:
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa

Abstract

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Introduction:

Impulsivity is a core feature of bipolar disorder (BD). The best definition of impulsivity is the predisposition to have rapid and unplanned reactions to internal and external stimuli without regard to the negative consequences of these actions to the impulsive individual or others. Thus, the aim of our study is to investigate the relationship between impulsivity, panic disorder (PD) comorbidity and panic spectrum symptoms in patients with BD.

Method:

247 eutimic patients were assessed with SCID-P, MOOD-SR, PAS-SR. Impulsivity dimension was defined on the basis BIS Scale score (version 11).

Results:

A backward stepwise logistic regression in bipolar patients with PAS explained score statistically much higher for impulsivity (pas +6.09 vs pas - 3.88 p < 001) and the difference is statistically significant stratifing for BD. A stepwise linear regression, corrected by age and gender, displayed significantly statistical correlation with impulsivity score and PAS-SR by cut-off 35 (OR = 1.210).

Conclusions:

In our sample BD eutimic patients explained score statistically much higher for impulsivity. This data confirm the presence of the trait impulsivity in BD eutimic patients. BD patients with a comorbid anxiety disorder seem to display significant higher levels of impulsivity when compared to patients without an anxiety disorder. Impulsivity was linked with atypical panic like symptoms more with PD diagnosis. Results suggest the presence of specific bipolar disorder endophenotipe. Further neurobiologies studies are needed to elucidate the implications and reasons of this association.

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Abstract
Copyright
Copyright © European Psychiatric Association 2012
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