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P0328 - Variations in the serotonin transporter genotype and potential endophenotypes for affective disorder

Published online by Cambridge University Press:  16 April 2020

M. Vinberg ,
E. Mellerup ,
P.K. Andersen ,
B. Bennike  and
L.V. Kessing
M. Vinberg
Affiliation:
Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
E. Mellerup
Affiliation:
Laboratory of Neuropsychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
P.K. Andersen
Affiliation:
Department of Biostatistic, University of Copenhagen, Copenhagen, Denmark
B. Bennike
Affiliation:
Laboratory of Neuropsychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
L.V. Kessing
Affiliation:
Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark

Abstract

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Background:

Variations in the serotonin transporter genotype and stressful life events may be associated with affective disorders.

Aim:

Firstly, to investigate whether the distribution of the alleles of the serotonin transporter gene is associated with a genetic predisposition for bipolar and unipolar disorder. Secondly, to investigate whether variations in the serotonin transporter (5-HTTLPR) genotype interact with stressful life events in relation to potential endophenotypes for affective disorders.

Method:

In a cross-sectional high-risk study, healthy monozygotic (MZ) and dizygotic (DZ) twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nation wide registers.

Results:

No differences were found between the 115 high- and 81 low-risk twins with respect to the distribution of the alleles of the serotonin transporter gene. However, the genotype interacted significantly with recent stressful life events on subclinical depressive symptoms and neuroticism score. No relation was found between 5-HTTLPR genotype and salivary cortisol.

Conclusion:

The distribution of the alleles of the serotonin transporter gene was not associated with a genetic predisposition for affective disorder. The presence of the short allele of the 5-HTTLPR gene and the experience of recent stressful life events seems to be associated with a higher level of subclinical depressive symptoms and higher neuroticism score.

Type
Poster Session I: Biological Markers
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S177 - S178
Copyright
Copyright © European Psychiatric Association 2008
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