To study role of psychosocial factors in formation of mental disorders (MD) in patients with diabetes mellitus (DM).

We examined 210 patients (age 48.57±8.65 years) with DM of type 2 and glucose tolerance disturbance (GTD) at Borderline States Department.

DM patients were diagnosed as having neurotic, stress-related (44%), and affective (14%), organic (35%), personality (7%) disorders. Method of logistic regression has identified totality of prognostic signs in values (Concordant; Somers'D) of Hosmer and Lemeshow's test (0,7-0,9). We studied significance of psychogenic factors (life events, medical, working, family-housing ones) in formation of mental disorders. Predictors were as follows: level of glycemia (p=0.0001), body mass index (p=0.0001), diabetic retinal angiopathy (p=0.02), family history (p=0.044). Psychosocial predictors: duration of MD (p=0.0001), age of onset of MD (p=0.0001), ratio of age of onset and duration of MD and DM (p=0.0001), disorders of neurotic and affective level (p=0.0001). Anosognosia DM was combined with anxiety, fears and fear of death, inappropriate assessment of their abilities, hypothymia, anxiousness, and vegetative dysfunctions.

Two-factor disperse analysis has identified relationship between level of glycemia on an empty stomach, MD (p=0.0001; p=0.007) and DM (p=0.003). Instability of blood glucose (4.63-19.3 mmol/l) was observed in 40% of patients with leading syndrome of depression. Depressive disorders contributed to quicker development or decompensation of DM 2 for the first six months.

High risk of complications of DM was associated with influence of psychostressors and depressive disorders. Treatment of patients requires interaction of therapist (endocrinologist), psychiatrist, and psychotherapist.