To study the role of psychosocial stressor factors in formation of neurotic and affective disorders in patients with PU of duodenum and stomach.

In Borderline States Department of MHRI TSC SB RAMSci we examined 245 patients (male - 111; female – 134; mean age 43,28±8,86 years) with peptic ulcer and mental disorders (MD) of neurotic and affective level appearing to be causes of seeking by patients for a psychiatrist. In 24,9% of them PU was diagnosed for the first time under conditions of a psychiatric hospital.

Method of logistic regression along with convenient for PU factors of “aggression” and “defense” predictors of psychosocial disadaptation and prognosis of PU development have been revealed in men (Concordant=84,6%, Somers'D=0.693), in women (Concordant=82,8%, Somers'D=0.660). From the first step sign “heredity” according to PU has constituted 24% (p=0.0001). Of significance were somatic factors: gastroduodenitis infected HP (p=0.0015), duodenogastric reflux (p=0.0015), gallstones (р=0.003), indices of immune status (р=0.0174). Significant psychosocial (stressor factors) predictors have been revealed: life events (p=0.0021), medical (p=0.0002), working, everyday ones (p=0.037). Mental disorders of depressive, anxious, asthenic spectrum (р=0.0001), duration (р=0.001) and age of onset of mental disorders (р=0.001), psychopathological syndrome (р=0.0009). Non-specific symptoms of PU are represented by psychovegetative paroxysms of fear of death (p=0.0006), cardialgias (p=0.008), abdomenalgias (p=0.005), hypochondriac fixation (p=0.001), hypothymia (р=0.0003), demonstrativeness (р=0.004). Perspective is assessment of interrelationship of somatic and mental factors in development of schemata of complex somatic and psychopharmacotherapy, psychotherapy of PU patients.