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P02-235 - PER3 VNTR as a Predictor of Sleep and Diurnal Preference in a Romanian Population

Published online by Cambridge University Press:  17 April 2020

B. Voinescu ,
A. Coogan  and
J. Thome
B. Voinescu
Affiliation:
Psychiatry, Clinical County Hospital of Emergency, Cluj-Napoca, Romania Physiology, University of Medicine and Pharmacy, Cluj-Napoca, Romania
A. Coogan
Affiliation:
Psychology, NUI Maynooth, Maynooth, Ireland
J. Thome
Affiliation:
Psychiatry, Swansea University, Swansea, UK

Abstract

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Objective

To evaluate whether a variable number tandem repeat (VNTR) in the human PER3 gene is linked with sleep or circadian phenotypes.

Methods

Seventy three people (age: 23-71; 41 males and 32 females) volunteered for this study. They completed a questionnaire containing the Romanian translations of the Composite Scale of Morningness, the Sleep Disorders Questionnaire, the Pittsburgh Sleep Quality Index, the Pittsburgh Insomnia Rating Scale, the Epworth Sleepiness Scale, the Multidimensional Fatigue Inventory, the Alcohol Use Disorders Identification Test and the Beck Depression Inventory II. Genotyping was performed on genomic DNA in blood.

Results

Sixteen subjects had the shorter allele (PER3 4/4), thirty one the longer one (PER3 5/5), while the rest were heterozygote (PER3 4/5). We found no statistically significant differences between the genotypes on any of the scales used.

Conclusions

In this small population, PER3 genotype predicted none of the investigated variables.

Type
Others
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E849
Copyright
Copyright © European Psychiatric Association 2010
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