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P0194 - Differences between patients with depressive disorder and healthy controls in relation to salivary Cortisol, psychopathology and results in neuropsychological testing

Published online by Cambridge University Press:  16 April 2020

V. Gapp ,
T. Wetterling ,
K. Israel-Laubinger ,
N. Helbing ,
L. Dibbelt  and
B. Weber
V. Gapp
Affiliation:
Clinic for Psychiatry, Psychosomatics and Psychotherapy, J. W Goethe University, Frankfurt, Germany
T. Wetterling
Affiliation:
Clinic for Psychiatry and Psychotherapy - Gerontopsychiatry, Vivantes Klinikum Hellersdorf, Berlin, Germany
K. Israel-Laubinger
Affiliation:
Clinic for Psychiatry, Psychosomatics and Psychotherapy, J. W Goethe University, Frankfurt, Germany
N. Helbing
Affiliation:
Clinic for Psychiatry, Psychosomatics and Psychotherapy, J. W Goethe University, Frankfurt, Germany
L. Dibbelt
Affiliation:
University Clinic of Schleswig Holstein, Schleswig Holstein, Germany
B. Weber
Affiliation:
Clinic for Psychiatry, Psychosomatics and Psychotherapy, J. W Goethe University, Frankfurt, Germany

Abstract

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The hypothalamic-pituitary-adrenal axis (HPA) is highly relevant in depressive disorders. Some investigations suggest that the HPA axis is altered in depressive disorders as indicated by higher awakening cortisol levels. There are also some results that show relations between cortisol level, psychopathology and neuropsychological performance. However, a systematic investigation of this relationship with a large and matched sample of patients and controls is missing. We tested 59 patients with depressive disorders and 75 healthy controls with tasks from the neuropsychological CANTAB and NEUROBAT battery. Before and after these tests we collected salivary samples. The study ended followed with an extensive measurement of psychopathology (e. g. BDI, HAM-D) and mood (visual analog scales).

The study revealed a significant relationship between salivary cortisol and results in tasks to executive function in the neuropsychological assessment in the control group but not in the patient group. There was no relationship between salivary cortisol and other cognitive performances. While patients with higher salivary cortisol levels reported worse mood, higher salivary levels in healthy controls were associated with better mood. These results could be related to different stress levels and different expectations regarding the examination of the groups.

Type
Poster Session II: Depression
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S249
Copyright
Copyright © European Psychiatric Association 2008
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