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P0178 - White matter abnormalities in obsessive-compulsive disorder: A diffusion tensor imaging study

Published online by Cambridge University Press:  16 April 2020

Y. Saito ,
K. Nobuhara ,
G. Okugawa ,
K. Takase ,
A. Tajika ,
T. Sugimoto ,
M. Maehara ,
H. Kurokawa ,
K. Ikeda  and
S. Sawada
...Show all authors
Y. Saito
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
K. Nobuhara
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
G. Okugawa
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
K. Takase
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
A. Tajika
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
T. Sugimoto
Affiliation:
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
M. Maehara
Affiliation:
Department of Radiology, Kansai Medical University, Osaka, Japan
H. Kurokawa
Affiliation:
Department of Radiology, Kansai Medical University, Osaka, Japan
K. Ikeda
Affiliation:
Department of Radiology, Kansai Medical University, Osaka, Japan
S. Sawada
Affiliation:
Department of Radiology, Kansai Medical University, Osaka, Japan
T. Kinoshita
Affiliation:
Department of Radiology, Kansai Medical University, Osaka, Japan

Abstract

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Background and Aims:

The corpus callosum (CC) is the largest interhemispheric white matter commissure connecting the cerebral hemispheres and plays a crucial role in interhemispheric communication and cognitive processes. The subdivisions of the CC were attempted to define corresponding areas of the cortex from which the fibers originate. Previous neuroanatomic studies of the CC provide impetus for investigating its role in obsessive-compulsive disorder (OCD).

Methods:

In this study diffusion tensor imaging (DTI) was employed to microstructural abnormalities of white matter of the CC in OCD patients. Nine patients with OCD and matched control subjects underwent DTI. Fractional anisotropy (FA), an index of the integrity of white matter tracts, was determined in the seven subdivisions of the CC.

Results:

Significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with one of controls. FA of the other subdivisions except the rostrum in OCD patients did not differ compared with control subjects. Higher FA in the rostrum correlated with lower Y-BOCS scores (r = -0.852, p = 0.004).

Conclusions:

The rostrum contains fibers from inferior premotor as well as medial and caudate/orbital prefrontal regions. These results supported the theory of dysfunction of prefrontal cortex and striatal circuits in OCD and suggested the implication of the orbitofrontal circuit for symptom severity in the OCD patients.

Type
Poster Session III: Obsessive Compulsive Disorders
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S353
Copyright
Copyright © European Psychiatric Association 2008
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