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P0142 - Response to antidepressant treatment by suicidal major affective disorder patients

Published online by Cambridge University Press:  16 April 2020

M. Pompili
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy Department of Psychiatry, Harvard Medical School & International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
M. Innamorati
Affiliation:
Università Europea Di Roma, Rome, Italy
A. Del Casale
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
C. Ferrara
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
A. Celentano
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
M. Angelone
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
S. Buffo
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
G. Manfredi
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
G. Giupponi
Affiliation:
Department of Psychiatry, Bolzano, Italy
G. Di Veroli
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
I. Berry
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
P. Girardi
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
R. Tatarelli
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
E. De Pisa
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
C. Comazzetto
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy
I. Falcone
Affiliation:
Department of Psychiatry, Sant'Andrea Hospital, University of Rome “la Sapienza”, Rome, Italy

Abstract

Objective:

To test the prognostic value of suicidal status in depressed patients for responses to antidepressant treatment.

Methods:

We evaluated treatment response and covariates in depressed patients diagnosed with DSM-IV major depressive (n=50) or bipolar disorders (n=32) treated initially in a day-hospital for 2 weeks, followed by 4 weeks of outpatient treatment with antidepressants, with or without a mood-stabilizer. Being suicidal was based on an item-3 of the 17-item Hamilton Depression Rating Scale (HDRS17) scored at ≥3 and verified by baseline clinical assessment; morbidity and improvement were based on the total of the remaining 16 nonsuicidal items (HDRS16).

Results:

Suicidal (n=31) and nonsuicidal subjects (n=51) were similar in baseline ratings of depressive symptom-severity (HDRS16), but were depressed longer and less likely to be married. Suicidality ratings improved by 36% during 6 weeks of treatment among initially suicidal patients, but other depressive symptoms (HDRS16) improved (13%) only half as much as in nonsuicidal subjects (25%), independent of diagnosis and treatment. Fewer than half as many suicidal subjects showed ≥20% improvement in HDRS16 scores.

Limitations:

Findings, based on diagnostically complex and relatively treatment-resistant subjects, may not generalize.

Conclusions:

Being suicidal may limit response to treatment in depressed major affective disorder patients, independent of diagnosis or overall symptomatic severity.

Type
Poster Session II: Bipolar Disorders
Copyright
Copyright © European Psychiatric Association 2008
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