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P01-356 - Casuistic Series with Escitalopram Treatment of Bpsd in Patients with Alzheimer's Disease

Published online by Cambridge University Press:  17 April 2020

J. Konrad  and
E. Topinkova
J. Konrad
Affiliation:
Dept. of Old Age Psychiatry, Psychiatricka Lecebna Havlickuv Brod, Havlickuv Brod, Czech Republic
E. Topinkova
Affiliation:
Dept. of Geriatrics, First Faculty of Medicine, Charles University Prague, Prague, Czech Republic

Abstract

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Objectives

Behavioral and psychological symptoms of dementia (BPSD) are common during the course of dementia and are associated with poor outcome for patients. There are some clinical data indicating that SSRI antidepressants have a positive influence on BPSD. Escitalopram has an excellent side-effect profile and might be a suitable treatment for BPSD in older demented patients.

Methods

An open-label observation of inpatients aged 65 to 90 years with a clinical diagnosis of probable AD and an MMSE score of 6 to 20 points and NPI total score ≥20 points treated with escitalopram for 8 weeks. The evaluation of improvement/worsening counted as ±10% change from baseline score in NPI and CMAI short. The results expressed in numbers of improved, unchanged and worsened patients.

Results

13 patients, 12 women and 2 men. The average age was 79.3 years, the average MMSE was 12.8 points. Three patients discontinued due to AEs (bronchopneumonia, progressive worsening of dementia, transfer to another institution). The other AEs were mild and not related to study medication.

 NPI patient scaleCMAI short scale
Baseline Day 1 (N=13)31.229.9
Day 14 (N=13)27.126.9
Day 28 (N=11)22023 7
Day 56 (N=10)16.921 5
2 unchanged3 unchanged
8 improved7 improved
(5 of them much improved) defined as ≥62% reduction of score(5 of them much improved) defined as ≥38% reduction of score

Conclusions

Most patients exhibited a reduction of BPSD, half of them with a very substantial reduction. Patients exhibited very good tolerance of the medication.

Type
Dementia / Gerontopshychiatry
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E564
Copyright
Copyright © European Psychiatric Association 2010
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