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P0132 - Familial loading in bipolar disorder and substance use disorder

Published online by Cambridge University Press:  16 April 2020

V. Camilleri ,
M. Doria ,
G.J. Massei ,
A. Oppo ,
L. Ravani ,
E. Fui ,
C. Ceccarini ,
I. Giunti ,
G. Macchia  and
A. Sbrana
...Show all authors
V. Camilleri
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
M. Doria
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
G.J. Massei
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
A. Oppo
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
L. Ravani
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
E. Fui
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
C. Ceccarini
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
I. Giunti
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
G. Macchia
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
A. Sbrana
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
M. Mauri
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy
G.B. Cassano
Affiliation:
Department of Psychiatry Neurobiology Pharmacology and Biotecnology, University of Pisa, Pisa, Italy

Abstract

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Background:

Bipolar disorder and substance use disorder have well documented genetic component. Among Axis I disorder bipolar subjects have highest comorbidity for alcohol and substance use disorder, ranging from 17 to 60%. Some Authors find a familial association between bipolar disorder and substance use disorder, suggesting the question if these disorders share a common genetic liability.

Aims:

To investigate familial loading in bipolar disorder (with and without alcohol/substance use disorder) and in patients with substance use disorder.

Methods:

Sampe (62 patients with bipolar disorder and alcohol/substance use disorder-DD, 23 patients with bipolar disorder-BD, 22 patients with substance use disorder without mood disorder-SUD) was recruited in Psichiatric clinic of Pisa and Dependance Department of Pisa and Bolzano. Instruments: SCID-IV-I/P for Axis I diagnosis and Family History Screen (Weissman, 2000).

Results:

Bipolar pts (DD and BD) have higher familial diathesis for manic and depresive episodes respect DUS probands (p≤0.001). Moreover DD show higher familial loading for alcohol/substance use respect BD (p=0.000). Abuser subjects (DD and SUD) show higher familiarity for conduct disorder respect BD (p=0.008)

Conclusions:

DD pts show a double familial loading, both for mood disorder (respect SUD), and for alcohol/substance use disorder (respect BD). Probably the familial loading for substance use disorder and mood disorder are distinct and they are both present in dual diagnosis patients.

Type
Poster Session II: Bipolar Disorders
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S231
Copyright
Copyright © European Psychiatric Association 2008
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