Skip to main content Accessibility help
×
Home

P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD

  • S.-C. Cho (a1), B.-N. Kim (a1), J.-W. Kim (a1), M.-S. Shin (a1), H.-W. Kim (a2), J.-W. Kang (a3) and Y.-H. Yang (a1)...

Abstract

Objectives

The aim of this study was to examine whether the presence of risk alleles of the norepinephrine transporter gene (SLC6A2) polymorphisms is associated with differences in regional cerebral blood flow (rCBF) measured by 99mTc-HMPAO single photon emission computerized tomography in a Korean sample of ADHD.

Methods

The present study included 24 children with ADHD (9.5±2.4 years), consisting of 20 boys and 4 girls, aged 6-16 years. We investigated the G1287A and -3081(A/T) polymorphisms of the SLC6A2. The rCBF was compared between the ADHD subjects with and without risk alleles at the G1287A polymorphism and at the -3081(A/T) polymorphism. Image analyses were performed with voxelwise t-statistics using SPM2.

Results

  1. 1) The ADHD subjects with the A allele (risk allele) at the G1287A polymorphism showed reduced perfusion in the left middle frontal gyrus, left inferior parietal lobule, precuneus, right superior frontal gyrus, and right superior parietal lobule as compared with ADHD subjects without the A allele (p< 0.001).

  2. 2) The ADHD subjects with the A allele at the G1287A polymorphism showed increased perfusion in the right middle frontal gyrus, right middle temporal gyrus, right superior temporal gyrus, right fusiform gyrus, right precentral gyrus, and right anterior lobe of cerebellum as compared with ADHD subjects without the A allele (p< 0.001).

  3. 3) No significant perfusion differences were found between ADHD subjects with and without the T allele (risk allele) at the -3081(A/T) polymorphism.

Conclusion

Our findings suggest that the SLC6A2 G1287A polymorphism might exert differential effects on rCBF in children with ADHD.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD
      Available formats
      ×

Copyright

P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD

  • S.-C. Cho (a1), B.-N. Kim (a1), J.-W. Kim (a1), M.-S. Shin (a1), H.-W. Kim (a2), J.-W. Kang (a3) and Y.-H. Yang (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

P01-188 - Regional Brain Perfusion Differences Associated with Norepinephrine Transporter Gene Polymorphisms in ADHD

  • S.-C. Cho (a1), B.-N. Kim (a1), J.-W. Kim (a1), M.-S. Shin (a1), H.-W. Kim (a2), J.-W. Kang (a3) and Y.-H. Yang (a1)...
Submit a response

Comments

No Comments have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *