On model of neurotic states properties of tranquilizers with benzodiazepine structure: alprozalam, lexilium, tranxen were studied.

Rating of anxiety (HARS), state of cellular immunity, pharmacokinetic (antipirine test).

At baseline total level of anxiety according to HARS constituted 17,3 ± 0,8 scores with anxious disorders assessed as 12,06 ± 0,6 scores, somatic manifestations – 4,41 ± 0,8 and neurovegetative reactions – 3,4 ± 0,35. During therapy with alprozalam, positive reverse dynamic of clinical symptoms was registered, leveling of neurovegetative manifestations. Peculiarity of lexilium is activation of factors of non-specific resistance, increase of percent of phagocyting neutrophiles both as compared with control and with indices at admission. Pharmacological action of tranxen was associated with normothymic, sedative action, presence of vegetostabilizing effect. Immunological dynamic during therapy with tranxen manifested itself in insignificant trend to normalization of cellular immunity. Pharmacokinetic of these preparations is as follows: constant of elimination of cassadan and tranxen has similar values (0,13 ± 0,031 min-1 и 0,12 ± 0,061 min-1), for lexilium this characteristic has lower values 0,075 ± 0,017 min-1 (P<0,05). Basic characteristics were permanent for all preparations and did not change in the course of the therapy.

Of most efficacy in mental anxiety is alprozalam; action of tranxen is more delicate. Somatic anxiety is better removed by lexilium. Alprozalam and tranxen are preparations of quick elimination; lexilium has a lower tempo of elimination. Alprozalam possesses an immunomodulating property, especially on indices of cellular immunity, lexilium activates phagocytosis, and tranxen is intact regarding immunity.