To study original galogen derivative ureas which are a perspective class pharmacological active substances.

Connection of M-chlorbenzhydrilurea, (Galodif), has been studied in a number of 780 linear and cyclic derivatives of urea.

Galodif, possesses high anticonvulsive activity at all models - the maximal electroshock (11,8 + 1,7) mg/kg, corasol (218,0+18,1) mg \kg, strichnin (252,0+32,1) mg/kg and camphor (37,2 + 4,2) the mg/kg spasmes, possesses the expressed central M-cholinolitic and weak H-cholinolitic action, blocks convulsive action tiosemicarbaside. The effective dose under the test of the maximal electroshock for mice is equal 11,8 mg/kg. On breadth anticonvulsive actions (LD50/ED50) preparation Galodif (218,0) surpasses phenobarbital (9,1), benzonal (6,9) and phenuron (36,5). Galodif in therapeutic doses does not change impellent activity and rough reactions at mice, prolonges the time of a drug sleeping (chlorhydrat (on 170 %), barbamil (on 175 %), hexobarbital on 131 %), does not show antireserpin action under the test reserpin hypotermia, does not influence on aphomorphin stereotipy and does not oppress developed conditioned reflex-defensive electroencephalografic the analysis has revealed deprime action Galodif on impellent area of a bark of greater hemispheres, n. intralaminary talamusa, n. caudatus and reticular formation of an average brain. In the mechanism anticonvulsive actions.

Thus, linear derivative ureas - preparation Galodif - possesses a wide spectrum anticonvulsive activity and is safe at long application including in conditions of a pathology of a liver. Besides the preparation corresponds pharmacoeconomy to the criteria shown to modern antiepileptical treatmeants.