Number of mental disorders, evolving as a result of old stress, is characterized of steady increase. Object of the work: determine the role of psychogenic and stress factors in the evolution of clinical forms of mental disorders. 84 patients (10 males and 74 females) from 18 to 64 years old were assessed. Each patient passed the questioning for the development of stress factors, where they specified one or several events of their life, which they qualified as a strong stress. The analysis of obtained data allowed to find out that 6 patients (7,14%) survived a death of child; 14 (16,67%) - death of husband and other members of family; 9 (10,71%) - a severe illness of the family member; 2 (2,38%) – an extremal situation with the life threat; 2 (2,38%) – a rape; 3 (3,57%) – a severe somatic disease; 8 (9,52%) - loss of work; for 7 (8,33%) of the subjects the alcoholization of husband became the main stress. In the most numerous group, consisting of 33 (39,29%) patients, the divorce was a reason for mental disorder. The study allowed to reveal, that the situations of death and illness of the relatives and kindered, divorce and alcoholization of the member of family became the cause of the development of depression (51,19%) and disorder of adaptation (30,95%). The anxious-phobic disorder developed in the patients (14,29%), which have lost the work. In the patients, who have had a severe somatic illness, a hypochondriac (2,38%) and anxious-phobic disorder (0,84%) were diagnosed.