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Outcomes of COVID-19 in Patients with Mental Disorders

Published online by Cambridge University Press:  01 September 2022

N. Petrova ,
M. Sivashova ,
V. Pashkovsky ,
G. Prokopovich  and
A. Gvozdetckii
N. Petrova*
Affiliation:
Saint-Petersburg University, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian Federation
M. Sivashova
Affiliation:
St. Petersburg State University, Department Of Psychiatry And Narcology, St. Petersburg, Russian Federation
V. Pashkovsky
Affiliation:
Saint-Petersburg University, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian Federation
G. Prokopovich
Affiliation:
North-Western State Medical University named after I.I. Mechnikov, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian Federation
A. Gvozdetckii
Affiliation:
North-Western State Medical University named after I.I. Mechnikov, Department Of Psychiatry And Addiction, Saint-Petersburg, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Clinical practice has shown that SARS-CoV-2 viral infection increases the likelihood of developing mental disorders.Clinical practice has shown that SARS-CoV-2 viral infection increases the likelihood of developing mental disorders.

Objectives

To analyze clinical indicators of patients with COVID-19 with mental disorders and to identify predictors of adverse outcomes associated with mental state on its basis.

Methods

The study included 97 patients, 41 men and 56 women (62.3±15.3 years of age). During the observation period, 26 people died and 71 people recovered. Data collection was carried out using a questionnaire (109 variables). Binary logistic regression and Cox proportional hazards regression were used.

Results

In the study group, death occurred on average after 11.5 days. In this group, the mental state of patients was more severe with a predominance of cases of delirium. With age, the probability of a fatal outcome increased by 1.03 with each year of life. The severity of mental disorder had a greater impact on the risk of death compared to age (p=0.003). Improvement of the mental state of patients during psychotropic therapy was associated with a reduction in the risk of an unfavorable outcome of coronavirus infection by 11.11 times. The greatest contribution to the unfavorable outcome was made by the severity of infection: the risk of death increased by 33.17 times.

Conclusions

A severe or extremely severe mental state increased the risk of death by 4.55 times. The most significant factor in predicting mortality was associated with the severity of the underlying disease.

Disclosure

No significant relationships.

Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S501
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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