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Neurofunctional Effects of Cannabis on Response Inhibition

Published online by Cambridge University Press:  16 April 2020

S. Borgwardt
Affiliation:
University Hospital Basel, Basel, Switzerland King's College London, London, UK
P. Allen
Affiliation:
King's College London, London, UK
S. Bhattacharyya
Affiliation:
King's College London, London, UK
P. Fusar-Poli
Affiliation:
King's College London, London, UK
J.A. Crippa
Affiliation:
Universidade de São Paulo, Sao Paulo, Brazil
M.L. Seal
Affiliation:
University of Melbourne, Melbourne, Australia
V. Fraccaro
Affiliation:
King's College London, London, UK
Z. Atakan
Affiliation:
King's College London, London, UK
R. Martin-Santos
Affiliation:
King's College London, London, UK
C. O'Carroll
Affiliation:
King's College London, London, UK
K. Rubia
Affiliation:
King's College London, London, UK
P.K. McGuire
Affiliation:
King's College London, London, UK

Abstract

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Background:

This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.

Methods:

Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.

Results:

Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.

Conclusions:

These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Type
S39-03
Copyright
Copyright © European Psychiatric Association 2009
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