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Negative symptoms predict functional outcome of early-onset psychosis

Published online by Cambridge University Press:  16 April 2020

J. Merchan-Naranjo
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
D. Fraguas
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
M.J. De Castro
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
M. Parellada
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
D. Moreno
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
A. Ruiz-Sancho
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
A. Cifuentes
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
M. Leiva
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
C. Arango
Affiliation:
Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain

Abstract

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Background and aims:

Psychosis with onset prior to 18 years of age, or early-onset psychosis (EOP), have a poorer prognosis than adult-onset psychosis. Further, a worse functional outcome of patients with EOP has been related to diagnosis of schizophrenia, severity of negative symptoms, behavioral problems, premorbid functioning, childhood onset, and insidious onset. We aim to examine the functional outcome of patients with EOP over a two-year follow-up.

Methods:

A total of 24 patients with first episode psychosis were enrolled. Subjects underwent a cross-sectional evaluation at the baseline visit that consisted of collecting sociodemographic data, including parental socioeconomic status as measured by the Hollingshead-Redlich Scale. Psychotic symptoms were assessed using the Spanish version of the Positive and Negative Syndrome Scale (PANSS). Social disability was measured with the Global Assessment of Functioning disability scale (GAF). Patients were assessed at a two-year follow-up. A linear regression analysis was used to predict the level of functioning (based on GAF scores) over the two-year follow-up. Variables entered into this equation were: GAF at two-year follow-up (as dependent variable), and gender, age at first onset, parental socioeconomic status, diagnosis, positive symptoms at baseline, and negative symptoms at baseline (as independent variables).

Results:

Negative symptoms at baseline were the only significant variable that predict the functional outcome at the two-year follow-up (p= 0.010).

Conclusions:

Functional prognosis of early-onset psychosis depends on the severity of negative symptoms, independently of diagnosis.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Copyright
Copyright © European Psychiatric Association 2007
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