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Mood disorders as a risk factor for family aggregation of somatic diseases

Published online by Cambridge University Press:  01 September 2022

E. Kasyanov  and
G. Mazo
E. Kasyanov*
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Translational Psychiatry, Saint-Petersburg , Russian Federation
G. Mazo
Affiliation:
Bekhterev National Medical Center for Psychiatry and Neurology, Translational Psychiatry, Saint-Petersburg , Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Mood disorders (MDs) are associated with somatic diseases and tend to aggregate in families. But there are limited studies on the risk of somatic diseases for relatives of patients with MDs.

Objectives

To assess whether a patient’s mood disorder diagnosis is associated with a family history of somatic disorders.

Methods

This cross-sectional family study included 36 patients with MDs (66.7% women; age - 32 [11.2] years) and 68 of their relatives, and 23 healthy individuals (56,5% women; age - 30.5 [6.9] years) and 53 of their relatives. A Pearson’s χ2 test was used to compare the frequencies of family history of somatic disease. Logistic regression models were used to determine the independent association of MDs, after adjusting for the effects of sex, age, with binary characteristics.

Results

Individuals with and without MDs had different frequencies of family history of cardiovascular (66,7% vs. 43,4%; p=0,03) and endocrinological diseases (47,2% vs. 39,1%; p=0,04). There were no statistically significant differences in the frequency of family history of gastrointestinal, pulmonary, urogenital and musculoskeletal diseases (p>0,05). Logistic regression revealed that MDs diagnosis in patients was a risk factor for cardiovascular (p=0.03, OR=3.5) and endocrinological disease (p=0.04, OR=3.7) in their relatives.

Conclusions

MDs are associated with the aggregation of somatic diseases in families. Future research is needed to clarify the biological reasons for this association.

Disclosure

No significant relationships.

Keywords

Depressionsomatic diseasesfamily studybipolar disorder
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S557
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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