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Monitoring of liver function in major depressive disorder treated with SSRI

  • P. Ifteni and A. Teodorescu (a1)

Abstract

Background

Major depressive disorder is one of the most prevalent psychiatric illnesses in the world affecting more than 12% of men and more than 21% of women in their lifetime. Selective serotonin reuptake inhibitors (SSRIs) are worldwide prescribed to treat depression. SSRIs drugs can cause drug-induced liver injury (DILI).

Aims

The aim of the study was to evaluate the liver function in patients treated with SSRI in order to detect DILI.

Methods

All the patients with first major depressive episode treated with the same SSRI antidepressant for at least 3 months between September 2013 and September 2015 were entered into the study. The hepatic function panel included aminotransferases, total and direct bilirubin, albumin, total protein, gamma glutamyl transferase (GGT), LDH cholesterol, hepatitis B virus (HBV), and hepatitis C virus (HCV).

Results

Of 134 subjects with MDD according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) who met inclusion criteria, 98 patients entered into study. Seventy-seven (76.5%) were treated with SSRI for at least 3 months with mean age were 45.4 (SD = 6.3), 65 women (66.3%). Five patients (5.1%) were newly diagnosed with hepatitis, and 10 (10.2%) presented elevated values of ALT, AST. The mean duration of depressive symptoms was 9.2 months (SD = 6.9).

Conclusions

The treatment with SSRI seems to be effective and safe in our sample. A relative small number of patients with MDD were diagnosed with viral hepatitis during this cross-sectional study. Further randomized and controlled trials are needed.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Copyright

Corresponding author

*Corresponding author.

Keywords

Monitoring of liver function in major depressive disorder treated with SSRI

  • P. Ifteni and A. Teodorescu (a1)

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Monitoring of liver function in major depressive disorder treated with SSRI

  • P. Ifteni and A. Teodorescu (a1)
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