Schizophrenia is associated with profound communication disorders resulting in a major social handicap. Hardy-Baylé and colleagues hypothesized that such impairments are related to a failure to process contextual integration. Previous studies based on event related potentials recordings (ERP) during semantic priming tasks have shown that schizophrenic patients have abnormal modulation of the N400 component. Supposedly, this electrical characteristic reflects an abnormal use of semantic context during word processing. However, the neural substratum underlying this pathological phenomenon remains poorly understood. To enrich knowledge inherited from ERP studies, we used magneto-encephalography (MEG) to determine the peculiarities (in anatomical and temporal terms) of the neural generators involved in semantic context integration in schizophrenia. The current study consisted in recording ERP and MEG signals during a French word-pairs lexical decision task (LDT). Subjects had to decide whether “target words” belonged to the lexicon or not, those words being preceded by word primes. The semantic relatedness between primes and targets varied (presence or absence) across two experimental conditions. Data obtained from a group of treated schizophrenic patients are compared to those from a healthy population. We report the preliminary results of schizophrenic subjects demonstrating that semantic priming elicits magnetic signals in the 300 to 500ms time window. Single subject's analysis of ERP and MEG profiles shows that the latter offers a different and complementary access to the brain response associated with LTD. Thus, MEG technique is suitable for investigating schizophrenic semantic priming abnormalities.