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Left hemispheric reductions of regional cerebral blood flow (rCBF) correlate with measures of dementia severity in patients with Alzheimer's disease: a SPECT study

Published online by Cambridge University Press:  16 April 2020

J Thome ,
L Frölich ,
M Scheubeck ,
G Hißnauer ,
T Becker ,
P Foley ,
GA Wiesbeck ,
GH Vince ,
K Maurer  and
M Rösler
J Thome*
Affiliation:
Department of Psychiatry
L Frölich
Affiliation:
Department of Psychiatry, University of Frankfurt, Main, Germany
M Scheubeck
Affiliation:
Department of Nuclear Medicine
G Hißnauer
Affiliation:
Department of Nuclear Medicine
T Becker
Affiliation:
Department of Psychiatry
P Foley
Affiliation:
Department of Psychiatry
GA Wiesbeck
Affiliation:
Department of Psychiatry
GH Vince
Affiliation:
Department of Neurosurgery,University of Würzburg
K Maurer
Affiliation:
Department of Psychiatry, University of Frankfurt, Main, Germany
M Rösler
Affiliation:
Department of Psychiatry
*
*Correspondence and reprints: Dr J Thome. Universitäts-Nervenklinik, FüchsleinstraBe 15, 97080 Würzburg, Germany.
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Summary

Regional cerebral blood flow (rCBF) values were measured by single photon emission computed tomography (SPECT) in different regions of the brain in 27 patients with DAT. Significant correlations were found between rCBF in left parieto-temporooccipital regions and psychometric test scores. Patients with hemisphere asymmetry in SPECT performed worse on psychometric tests. SPECT did not permit prediction of or differentiation between depressive and psychotic symptoms.

Keywords

Alzheimer’s diseasefunctional diagnosisSPECTpsychometryhemisphere asymmetry
Type
Short communication
Information
European Psychiatry , Volume 11 , Issue 6 , 1996 , pp. 314 - 318
Copyright
Copyright © Elsevier, Paris 1996

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