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Late-onset schizophrenia patients with social phobia receive higher doses of antipsychotics compared patients without social phobia: results of an observational study

Published online by Cambridge University Press:  01 September 2022

V. Pochueva ,
M. Savina  and
V. Sheshenin
V. Pochueva*
Affiliation:
FSBSI “Mental Health Research Centre”, Geriatric Psychiatry, Moscow, Russian Federation
M. Savina
Affiliation:
FSBSI “Mental Health Research Centre”, Geriatric Psychiatry, Moscow, Russian Federation
V. Sheshenin
Affiliation:
FSBSI “Mental Health Research Centre”, Geriatric Psychiatry, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Social phobia is frequent comorbidity in schizophrenia. It`s clinical correlates and consequencies for clinical practice in late-onset schizophrenia (LoS) are unclear.

Objectives

The study aimed to compare clinical correlates and therapeutic options in LoS patient with and without social phobia.

Methods

16 LoS patients with social phobia (ICD-11 diagnosis, age 59,6±6,2, 25% males) were compared with 16 LoS patients without social phobia (69,9±10,9, 0% males). Results of clinical assessment (PANSS, HDRS-17), cognitive examination (MMSE, MoCA), CT data were analysed. Type of antipsychotics (conventional\conconventional) was registed, dose of antipsychotics and antidepressants was randed from 1 (low) to 3 (high). Mann-Whitney test and χ2statistic was used.

Results

There was no group differences in age, age manifestation, illness duration, number of psychotic episodes, PANSS and HADRS scores, rates results of cognitive tests, atrophy scores, length of hospital state, types of received antipsychotics. LoS patients with social phobia received more frequently medium and high doses of antipsychotics than LoS patient without social phobia (χ2 (2)=6,432, p=0,040).

Conclusions

Increased doses of antypsychotics in patients with social phobia don`t correlate with severity of psychotic symptoms and nay reflect some treatment resistance as well as misinterpretation of symptoms of social phobia as insufficient retreat of the psychosis. Active detection of social phobia is significant for treatment optimization.

Disclosure

No significant relationships.

Keywords

old agelate onset schizophreniaantipsychoticssocial phobia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S248
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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