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In vivo exploration of brain phosphorus 31 metabolism in patients with senile dementia of Alzheimer type

Published online by Cambridge University Press:  16 April 2020

G Mecheri ,
Y Bissuel ,
J Dalery ,
JL Terra ,
G Balvay ,
B Roussel  and
M Marie-Cardine
G Mecheri
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
Y Bissuel
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
J Dalery
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
JL Terra
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
G Balvay
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
B Roussel
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
M Marie-Cardine
Affiliation:
CHS, Le Vinatier, 95, boulevard Pinel, 69677Bron Cedex, France
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Summary

In vivo NMR 31p spectroscopy is a non invasive, non ionizing method of exploration of energy and phospholipid metabolism in the brain. This study consisted of comparing 31p spectra in five patients with Senile Dementia of Alzheimer Type (SDAT) with those of four controls of similar ages. Abnormal phosphonionocsters (PME) concentrations, either high or low, were found in the patients, but statistical analysis did not elicit any significant difference relative to controls.

Keywords

NMR spectroscopySenile Dementia of Alzheimer Typephosphomonoestersmembrane pathology
Type
Rapid communication
Information
European Psychiatry , Volume 9 , Issue 2 , 1994 , pp. 105 - 109
Copyright
Copyright © European Psychiatric Association 1994

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