Hostname: page-component-848d4c4894-mwx4w Total loading time: 0 Render date: 2024-06-19T22:44:45.943Z Has data issue: false hasContentIssue false

Imaging drug action in schizophrenia: research update

Published online by Cambridge University Press:  16 April 2020

Marc Laruelle
Affiliation:
Division of Functional Brain Mapping, New York State Psychiatric Institute, Columbia University, New York, NY, USA
Anissa Abi-Dargham*
Affiliation:
Department of Psychiatry, Columbia University, New York, NY, USA
*
*E-mail address:aa324@columbia.edu (A. Abi-Dargham).
Get access

Extract

Functional neuroimaging using techniques such as positron emission tomography (PET) and single photon emission computerised tomography (SPECT) provide a direct in vivo assessment of the expression and function of neuroreceptors, transporters and enzymes. This article examines the technical aspects of molecular imaging and the application of those techniques in drug development.

Type
Research Article
Copyright
Copyright © 2003 European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abi-Dargham, A, Gil, R, Krystal, Jet al. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am J Psychiatry 1998;155(6):761–7.Google Scholar
Bigliani, V, Mulligan, RS, Acton, PDet al. In vivo occupancy of striatal and temporal cortical D2/D3 dopamine receptors by typical antipsychotic drugs. [123I]epidepride single photon emission tomography (SPET) study. Br J Psychiatry 1999;175:231–8.CrossRefGoogle ScholarPubMed
Bigliani, V, Mulligan, RS, Acton, PDet al. Striatal and temporal cortical D2/D3 receptor occupancy by olanzapine and sertindole in vivo: a [1231]epidepride single photon emission tomography (SPET) study. Psychopharmacology (Berl) 2000;150(2):132–40.CrossRefGoogle Scholar
Bressan, RA, Erlandsson, K, Jones, HMet al. Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [1231]-epidepride SPET study. J Clin Psychopharmacol 2003;23(1):5–14.CrossRefGoogle Scholar
Choi, SR, Hou, C, Oya, Set al. Selective in vitro and in vivo binding of [1251]ADAM to serotonin transporters in rat brain. Synapse 2000;38:403–12.3.0.CO;2-Z>CrossRefGoogle Scholar
Farde, L, Wiesel, FA, Halldin, Cet al. Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 1988;45:71–6.CrossRefGoogle ScholarPubMed
Haber, SN, McFarland, NR. The concept of the ventral striatum in nonhuman primates. Ann NY Acad Sci 1999;877:33-48.CrossRefGoogle ScholarPubMed
Kapur, S, Zipursky, RB, Remington, G.et al. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychol 1998;155:921–8.CrossRefGoogle ScholarPubMed
Kapur, S, Zipursky, R, Roy, Pet al. The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol a PET study. Psychopharmacology 1997;131:148–52.CrossRefGoogle ScholarPubMed
Kessler, RM, Whetsell, WO, Ansari, MSet al. Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride. Brain Res 1993;609:237–343.CrossRefGoogle ScholarPubMed
Koepp, MJ, Gunn, RN, Lawrence, ADet al. Evidence for striatal dopamine release during a video game. Nature 1998;393(6682):266–8.CrossRefGoogle ScholarPubMed
Laruelle, M, Abi-Dargham, A.Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies. J Psychopharmacol 1999;13(4):358–71.CrossRefGoogle ScholarPubMed
Laruelle, M, Slifstein, M, Huang, Y.Positron emission tomography: imaging and quantification of neurotransporter availability. Methods 2002;27(3):287–99.CrossRefGoogle ScholarPubMed
Laruelle, M, Abi-Dargham, A, Van Dyck, CHet al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 1996;93:9235–40.CrossRefGoogle ScholarPubMed
Marek, K, Jennings, D, Seibyl, J.Do dopamine agonists or levodopa modify Parkinson's disease progression? Eur J Neurol 2002;9(3): 15–22.CrossRefGoogle ScholarPubMed
Martinez, D, Hwang, D-R, Mawlawi, Oet al. Differential occupancy of somatodendritic and postsnaptic 5HT1A receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans. Neuropsychophamacology 2001;24:209–29.CrossRefGoogle Scholar
Martinot, JL, Paillere-Martinot, ML, Poirner, MHet al. In vivo characteristics of dopamine D2 receptor occupancy by amisulpnde m schizophrenia. Psychopharmacology 1996;124:154–8.CrossRefGoogle Scholar
Mathis, CA, Wang, Y, Holt, DPet al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003;46(13) 2740–54.CrossRefGoogle ScholarPubMed
Nyberg, S, Olsson, H, Nilsson, Uet al. Low striatal and extra-striatal D2 receptor occupancy during treatment with the atypical antipsychotic sertmdole. Psychopharmacology 2002:162:37-41.CrossRefGoogle Scholar
Parkinson Disease Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. J Am Med Assoc 2002;287:1653–61.CrossRefGoogle Scholar
Pilowsky, LS, O'Connell, P, Davies, Net al. In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole - a 1231IBZM single photon emission tomography (SPET) study. Psychopharmacology (Berl) 1997;130(2):152–8.CrossRefGoogle ScholarPubMed
Stephenson, CM, Bigliani, V, Jones, HMet al. Striatal and extra-stria-tal D(2)/D(3) dopamine receptor occupancy by quetiapine in vivo. [123I]-epidepnde single photon emission tomography (SPET) study. Br J Psychiatry 2000;177:408–15.CrossRefGoogle ScholarPubMed
Strafella, AP, Paus, T, Barrett, Jet al. Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci 2001;21(15):RC157.CrossRefGoogle ScholarPubMed
Suehiro, M, Scheffel, U, Ravert, HTet al. [1C](+ )McN5652 as a radiotracer for imaging serotonin uptake sites with PET. Life Sci 1993;53(11):883–92.CrossRefGoogle Scholar
Talvik, M, Nordstrom, AL, Nyberg, Set al. No support for regional selectivity in clozapine-treated patients: a PET study with [HC]raclopride and [11C]FLB 457. Am J Psychiatry 2001;158(6):926–30.CrossRefGoogle Scholar
Xiberas, X, Martinot, JL, Mallet, Let alExtrastriatal and striatal D(2) dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. Br J Psychiatry 2001:179 503–8.CrossRefGoogle ScholarPubMed
Xiberas, X, Martinot, JL, Mallet, Let al. In vivo extrastriatal and striatal D2 dopamine receptor blockade by amisulpnde in schizophrenia J Clin Psychopharmacol 2001;21(2):207–14.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.