This case study intends to describe the features of a serious schizophrenic psychosis in a ethiopian immigrant woman that is arrived in Italy twenty years ago with her italian husband that worked in Ethiopia. This person had a excellent health when she leaves from Africa to Italy in order to live her life in our nation.

She had a high cultural level as her family and she get married to husband ongly for love and not for other interest.

Today this woman presents a very serious behavioural regression as physical conditions.

She is a non-responder to psychopharmacological therapy (first and second generation antipsychotics).

There are many problems to treat this chronic condition with hight disability and we must consider the importance of cultural aspects respect to clinical elements.