Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-25T04:50:54.960Z Has data issue: false hasContentIssue false

A family interview study of schizophrenia, schizoaffective disorder, and major mood disorder: updated findings

Published online by Cambridge University Press:  16 April 2020

HG Pope Jr
Affiliation:
Mailman Research Center, McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, USA
D Yurgelun-Todd
Affiliation:
Mailman Research Center, McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, USA
Get access

Summary

Data from an ongoing family interview study suggest that schizoaffective probands - including even those with a very brief history of a major depressive or manic syndrome - display a high prevalence of major mood disorders in their first-degree relatives. In this respect, schizoaffective probands proved significantly different from ‘pure’ schizophrenic probands, but not significantly different from bipolar probands.

Type
Original article
Copyright
Copyright © Elsevier, Paris 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abrams, RTaylor, MA (1983) The genetics of schizophrenia; A reassessment using modern criteria. Am J Psychiatry 140, 171175Google ScholarPubMed
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd ed revised). Washington, DCGoogle Scholar
Baron, MGruen, RRainer, JDKane, JAsnis, LLord, S (1985) A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia. Am J Psychiatry 142, 447455Google ScholarPubMed
Coryell, WZimmerman, M (1988) The heritability of schizophrenia and schizoaffective disorder: a family study. Arch Gen Psychiatry 45, 323327CrossRefGoogle ScholarPubMed
Frangos, EAlthanassenas, GTsitourides, SKatsanou, NAlexandrakou, P (1985) Prevalence of DSM III schizophrenia among the first-degree relatives of schizophrenic probands. Acta Psychialr Scand 72, 382386CrossRefGoogle ScholarPubMed
Gershon, ES (1988) Genetics. In: Manic-Depressive Illness (Goodwin, FKJamison, KR eds). Oxford University Press, New YorkGoogle Scholar
Gershon, ESDeLisi, LEHamovit, JNurnberger, JIMaxwell, MESchreiber, JDauphinais, DDingman, CWGuroff, JJ (1988) A controlled family study of chronic psychoses: schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 45, 328336CrossRefGoogle ScholarPubMed
Guze, SBCloninger, CRMartin, RLClayton, PJ (1983) A follow-up and family study of schizophrenia. Arch Gen Psychiatry 40, 12731276CrossRefGoogle ScholarPubMed
Kendler, KSGruenberg, AMTsuang, MT (1985) Psychiatric illness in first-degree relatives of schizophrenic and control patients: a family study using DSM III criteria. Arch Gen Psychiatry 42, 770779CrossRefGoogle ScholarPubMed
Pope, HG JrCohen, BMLipinski, JFYurgelun-Todd, D (1988) DSM-III criteria for mood disorders and schizophrenia: a preliminary appraisal using family interview findings. Psychiatry Psychobiol 3, 159169Google Scholar
Robins, LNHelzer, JECroughan, JRatcliff, KS (1981) National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry 38, 381389CrossRefGoogle ScholarPubMed
Slater, ECowie, V (1971) The Genetics of Mental Disorders. Oxford University Press, LondonGoogle Scholar
Spitzer, RLWilliams, JBWGibbon, M (1988) Structured Clinical Interview for DSM III-R. Biometrics Research Division, New York State Psychiatric Institute, New YorkGoogle Scholar
Tsuang, MT (1991) Morbidity risks for schizophrenia and affective disorders among first-degree relatives of patients with schizoaffective disorders. Br J Psychiatry 158, 165170CrossRefGoogle ScholarPubMed
Wegner, JTCatalano, FKane, JM (1985) Schizophrenics with tardive dyskinesia: neuropsychological deficit and family psychopathology. Arch Gen Psychiatry 42, 860865CrossRefGoogle ScholarPubMed
Weissman, MMGershon, ESKidd, KKPrusoff, BALeckman, JFDibble, EHamovit, JThompson, WDPauls, DLGuroff, JJ (1984) Psychiatric disorders in the relatives of probands with affective disorders: the Yale University-National Institute of Mental Health Collaborative Study. Arch Gen Psychiatry 41, 1321CrossRefGoogle ScholarPubMed
Williams, JBWGibbon, MFirst, MBSpitzer, RLDavies, MBorus, JKane, JPope, HG JrRounsaville, BWittchen, HUThe structured Clinical Interview for DSM III-R (SCTD), II: Multi-site test - retest reliability. Arch Gen Psychiatry 49, 630636CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.