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Eveningness chronotype and depressive affective temperament associated with higher high-sensitivity C-Reactive Protein in Unipolar and Bipolar Depression

Published online by Cambridge University Press:  19 July 2023

L. Orsolini ,
S. Pompili ,
A. Cicolini ,
L. Ricci  and
U. Volpe
L. Orsolini
Affiliation:
Unit of Clinical Psychiatry, Department of Neurosceinces/DIMSC, Università Politecnica delle Marche, Ancona, Italy
S. Pompili*
Affiliation:
Unit of Clinical Psychiatry, Department of Neurosceinces/DIMSC, Università Politecnica delle Marche, Ancona, Italy
A. Cicolini
Affiliation:
Unit of Clinical Psychiatry, Department of Neurosceinces/DIMSC, Università Politecnica delle Marche, Ancona, Italy
L. Ricci
Affiliation:
Unit of Clinical Psychiatry, Department of Neurosceinces/DIMSC, Università Politecnica delle Marche, Ancona, Italy
U. Volpe
Affiliation:
Unit of Clinical Psychiatry, Department of Neurosceinces/DIMSC, Università Politecnica delle Marche, Ancona, Italy
*
*Corresponding author.

Abstract

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Introduction

Several studies investigated the role of inflammation in the etiopathogenesis of psychiatric disorders, by also evaluating how CRP may exert a pathoplastic and/or psychopatological role in mood disorders.

Objectives

The aim of our cross-sectional study is evaluating the high-sensitivity C-reactive-protein (hsCRP) levels in a cohort of unipolar and bipolar depressive inpatients, in relation with psychopathological, temperamental and chronotype features.

Methods

Among 313 screened inpatients, we recruited 133 moderate-to-severe depressive patients who were assessed for hsCRP levels, chronotype with Morningness-Eveningness Questionnaire (MEQ) and affective temperament with Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS).

Results

hsCRP levels were significantly higher among those with previous suicide attempt (p=0.05), death (p=0.018) and self-harm/self-injury thoughts (p=0.011). In addition, hsCRP levels were significantly higher among patients with hypertension (p=0.020) and dyslipidemia (p=0.013). Moreover, positive correlation were found between hsCRP levels and the number of illness of years (p<0.001). Significant positive correlation were found between hsCRP levels and depressive (p<0.001) and cyclothymic (p<0.001) affective temperaments, while a negative correlations were reported between hsCRP levels and hypertimic (p<0.001) and irritable (p=0.029) affective temperaments. Eveningness chronotypes subject displayed higher hsCRP levels compared to intermediate-type and morningness-type chronotypes (p<0.001). Linear regression analyses, adjusted for all covariates, demonstrated that higher scores at the TEMPS-M depressive, while lower scores at the hyperthymic and irritable affective temperaments [F=88.955, R2=0.710, p<0.001] and lower MEQ scores [F=75.456, R2=0.405, p<0.001] statistically significantly predicted higher hsCRP.

Conclusions

Eveningness chronotype and a depressive affective temperament appeared to be associated with higher hsCRP levels during moderate-to-severe unipolar and bipolar depression. Further longitudinal and larger studies should better characterise patients with mood disorders by investigating the influence of chronotype and temperament.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S247
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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