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Evaluation of the Relationship Between Suicide Behavior and SIRT-1 Gene in Patients with Schizophrenia and Other Psychotic Disorders

Published online by Cambridge University Press:  01 September 2022

E. Uçak ,
M. Aydin ,
N. Koçak  and
K. Altınbaş
E. Uçak
Affiliation:
Selçuk University, Faculty of Medicine, Psychiatry, Konya, Turkey
M. Aydin*
Affiliation:
Selçuk University, Faculty of Medicine, Psychiatry, Konya, Turkey
N. Koçak
Affiliation:
Selçuk University, Faculty of Medicine, Genetics, Konya, Turkey
K. Altınbaş
Affiliation:
Selçuk University, Faculty of Medicine, Psychiatry, Konya, Turkey
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia is a mental disorder with a high risk of suicide, which is one of the leading causes of early death in schizophrenia patients.

Objectives

It was aimed to examine the relationship between the SIRT1 gene and suicidal behavior in patients with schizophrenia, to identify specific polymorphisms and to provide individual protective approaches by predicting suicidal behavior.

Methods

100 patients with schizophrenia were included in our study. The SIRT1 gene was analyzed using the whole exome sequencing method, and 22 SNPs were identified. In addition, participants’ socio-demographic, psychiatric history, and suicidal behavior evaluation form data were recorded. A comparison was made between the two groups according to suicidal behavior.

Results

When sociodemographic and psychiatric history of the participants were compared in terms of suicidal behavior, no significant difference was found. SIRT1 gene SNP; rs2236318; (TT genotype), rs10997870 (GG genotype) was associated about 4 times increased risk in suicidal behavior; rs41299232 (CC genotype) 3.7 times; rs7896005 (AA genotype) with 3.4 times also. Although rs201230502 (TC genotype) and rs36107781 (TC genotype) were more common in the group with suicidal behavior, they lost their significance in regression analysis due to the low number of cases.

Conclusions

Our study showed that schizophrenia has many risks that increase suicidal behavior , but clinical and sociodemographic data are insufficient to predict suicidal behavior. Considering the inheritability of the disease and the effect of genetics on behavior, SIRT1 gene SNP; (rs2236318, rs10997870, rs41299232, rs7896005, rs201230502 and rs36107781) genotypes were found to be associated with suicidal behavior in schizophrenia patients.

Disclosure

No significant relationships.

Keywords

schizophréniaGeneticsSuicidesirtuin1
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S358
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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