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EPA-1800 – Efficacy and Tolerability of Oral Caffeine with or Without Biperiden for Cocaine Detoxification in An Inpatient Setting: A Double Blind, Randomized, Placebo-Controlled Clinical Trial

Published online by Cambridge University Press:  15 April 2020

C. Roncero ,
M. Casas ,
S. Valero ,
L. Grau-López ,
B. Gonzalvo ,
A. Egido ,
C. Daigre ,
J. Alvarós ,
S. Gómez-Baeza  and
M. Corominas
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C. Roncero
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
M. Casas
Affiliation:
Psychiatry, Vall d’Hebron University Hospital, Barcelona, Spain
S. Valero
Affiliation:
Psychiatry, Vall d’Hebron University Hospital, Barcelona, Spain
L. Grau-López
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
B. Gonzalvo
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
A. Egido
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
C. Daigre
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
J. Alvarós
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
S. Gómez-Baeza
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
M. Corominas
Affiliation:
Psychiatry, Vall d’Hebron University Hospital, Barcelona, Spain
E. Ros-Cucurrull
Affiliation:
Outpatient Drug clinic. Psychiatry Departament-ASPB, Vall d’Hebron University Hospital, Barcelona, Spain
X. Castells
Affiliation:
Pharmacology, Vall d’Hebron University Hospital, Barcelona, Spain

Abstract

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Purpose

The aim of this study was to test the efficacy of caffeine with or without biperiden in the treatment of cocaine dependent patients.

Methods

A randomized, double blind, placebo-controlled clinical trial has been carried out in an inpatient regime during up to 13 days. Eligible patients were randomized to caffeine plus biperiden or caffeine plus biperiden placebo or caffeine placebo plus biperiden placebo.

Findings

Eighty five treatment-seeking patients were enrolled in this study. Patients were stabilized with a mean caffeine dose up to 15 mg/Kg. Results show that all three treatments are well tolerated and a clear reduction in cocaine withdrawal and craving was observed. Nevertheless, no statistically significant differences were found between groups in any outcome.

Conclusion

This study shows that inpatient cocaine detoxification with high caffeine doses, with or without biperiden, is well tolerated and allows further research on the usefulness of caffeine in the treatment of cocaine withdrawal and craving. Nevertheless, the selection of an inpatient hospital regime hampered the demonstration of the superiority of caffeine treatment versus placebo.

Type
P01 - Addictive Behaviours
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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