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EPA-1565 - Oxytocin Response to Social Exclusion in Chronically Depressed Patients

Published online by Cambridge University Press:  15 April 2020

L. Sabass
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
A. Palagyi
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
C. Bauriedl-Schmidt
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
M.C. Mauer
Affiliation:
Department of Psychology Clinical Psychology, University of Innsbruck, Innsbruck, Austria
T. Daltrozzo
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
N. Sarubin
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
B. Renneberg
Affiliation:
Department of Psychology, Freie Universität Berlin, Berlin, Germany
A. Buchheim
Affiliation:
Department of Psychology Clinical Psychology, University of Innsbruck, Innsbruck, Austria
P. Falkai
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
P. Zill
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
F. Padberg
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany
A. Jobst
Affiliation:
Clinic for Psychiatry and Psychotherapy Department of Psychotherapy and Psychosomatics, Ludwig-Maximilians-University, Munich, Germany

Abstract

Objective

Ostracism (social exclusion) has been found to be a remarkable stress factor to mentally ill people with difficulties in situations of social interaction. In an earlier study it was found that patients with borderline personality disorder (BPD) showed differences in oxytocin dysregulation by having lower oxytocin plasma levels during a social exclusion paradigm (Jobst et al., 2013, submitted). To our knowledge, this is the first study investigating neuroendocrinological changes of social exclusion in chronically depressed patients. Chronic depression (CD) is associated with poor social functioning and behavioral interpersonal problems which are considered to be based on the non-responsiveness of CD patients to environmental consequences.

Methods

To manipulate a situation of social exclusion we used the Cyberball Paradigm, a virtual ball tossing game which has been well validated and applied in numerous previous studies on the effects of social exclusion. 19 CD patients (according to DSM-IV) and 19 healthy controls matched for gender, age and education underwent repeated neuroendocrine measurements in a standardized laboratory setting during the Cyberball Paradigm. Assessments of psychological variables as well as measurements of oxytocin plasma levels were performed at baseline, 5 min, 15 min and 40 min after Cyberball.

Results/Discussion

As an association of interpersonal problems in BPD with oxytocin dysregulation has been found, we suggest differences in changes of oxytocin levels in a social exclusion situation in CD patients versus healthy subjects. The data will be presented and discussed in relation to specific interpersonal problems of patients suffering from CD.

Type
P08 - Depression
Copyright
Copyright © European Psychiatric Association 2014
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