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EPA-1313 - Influence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 Genetic Polymorphisms in Antidepressant Treatment Phenotypes

  • M. Santos (a1), L. Lima (a2), J. Mota-Pereira (a3), A. Cruz (a4), R. Medeiros (a1), S. Carvalho (a1), P. Pimentel (a1), D. Maia (a1), D. Correia (a1) and S. Gomes (a1)...

Abstract

Introduction

Several studies associated Major Depressive Disorder (MDD) with an increased production of pro-inflammatory cytokines, such as interleukin 6 (IL-6). Serum IL-6 levels were found to be significantly increased in subjects with MDD and with Treatment Resistant Depression (TRD). Moreover, ketamine, a drug with fast-acting antidepressant properties, has proven to reduce IL-6 levels in rat prefrontal cortex and hippocampus. However, despite the clear influence of IL-6 in the pathophysiology of depression and in antidepressant response, studies evaluating the impact of IL-6 functional genetic polymorphisms on treatment response phenotypes are scarce.

Objectives

We aim to evaluate the role of IL6-174G>C, IL6-6331T>C and IL6R D358A A>C functional polymorphisms in antidepressant treatment phenotypes, specifically remission, relapse and TRD.

Methods

We genotyped the referred polymorphisms in a subset of 80 MDD patients followed at Hospital Magalhães Lemos, Portugal, within a period of 18 months.

Results

We found that patients carrying IL6-174 GG genotype are more prone to develop TRD (OR=4.125; 95%CI: [1.151-14.786]; p=0.038). We also observed that patients carrying IL6-6331 TC genotype have a higher risk of relapse (OR=3.988; 95%CI: [1.176-13.516]; p=0.022), and present a lower time to relapse, TC: 26 weeks vs. TT: 45 weeks (p=0.041, Log-rank test). No association was found between IL6R D358A genetic polymorphism and any of treatment phenotypes.

Conclusions

The IL6-174G>C and IL6-6331T>C polymorphisms influence antidepressant treatment response in our subset of MDD patients. These polymorphisms may possibly contribute to the elevated IL-6 levels found in patients with TRD. This research was partially supported by an AstraZeneca Grant

Copyright

EPA-1313 - Influence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 Genetic Polymorphisms in Antidepressant Treatment Phenotypes

  • M. Santos (a1), L. Lima (a2), J. Mota-Pereira (a3), A. Cruz (a4), R. Medeiros (a1), S. Carvalho (a1), P. Pimentel (a1), D. Maia (a1), D. Correia (a1) and S. Gomes (a1)...

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EPA-1313 - Influence of il6-174g>c, il6-6331t>c and il6r d358a a>c il-6 Genetic Polymorphisms in Antidepressant Treatment Phenotypes

  • M. Santos (a1), L. Lima (a2), J. Mota-Pereira (a3), A. Cruz (a4), R. Medeiros (a1), S. Carvalho (a1), P. Pimentel (a1), D. Maia (a1), D. Correia (a1) and S. Gomes (a1)...
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