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Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis

Published online by Cambridge University Press:  16 April 2020

Hubertus Himmerich ,
Armin Szegedi ,
Christoph Klawe ,
Ion Anghelescu  and
Matthias J. Müller
Hubertus Himmerich*
Affiliation:
Max Planck Institute of Psychiatry, Kraepelinstraße 2–10, 80804Munich, Germany
Armin Szegedi
Affiliation:
Department of Psychiatry, University of Mainz, Untere Zahlbacher Straße 8, 55131Mainz, Germany
Christoph Klawe
Affiliation:
Department of Psychiatry, University of Mainz, Untere Zahlbacher Straße 8, 55131Mainz, Germany
Ion Anghelescu
Affiliation:
Department of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, Eschenallee 3, 14050Berlin, Germany
Matthias J. Müller
Affiliation:
Department of Psychiatry, University of Mainz, Untere Zahlbacher Straße 8, 55131Mainz, Germany
*
*Corresponding author. E-mail address: himmerich@mpipsykl.mpg.de (H. Himmerich).
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Abstract

A female patient with multiple sclerosis (MS) suffered from an acute psychotic disorder after taking distigmine bromide for detrusor dysfunction. She showed a dramatic relief of her symptoms after the medication, distigmine bromide, was stopped. Distigmine is not supposed to penetrate the blood-brain barrier (BBB). However, in MS patients a leakage of the BBB could be hypothesized.

Keywords

Distigmine bromideMultiple sclerosisBlood-brain barrier
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 6 , October 2003 , pp. 318 - 319
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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