It's sometimes difficult to choose whether drug therapy or/and psychotherapy for adolescents with anxiety-depressive disorders. An antidepressant's therapy is sometimes complicated by a defensible position of adolescent, because the prolonged course of antidepressants has negative side effects. An early improvement plays an important role when psychotherapy is used. In most cases it helps to achieve prolonged remission and to avoid relapses.

It's necessary to form a rational approach in therapy of anxiety-depressive disorders by combination of drug therapy and psychotherapy.

35 adolescent in the age of 15 – 17 with symptoms of anxiety – depressive disorders were observed. SSRI fluvoxamine maleate and course of cognitive psychotherapy were used. The effectiveness of therapy was valued at once and also in 6 and 12 months after the therapy. The degree of improvement, remission, convalescence and exacerbation were measured by Beck's scale.

Those adolescent who received a complex therapy had an early positive results. Also they had more expressive improvement at once and in 6 and 12 month after course of the therapy and had a lower rate of exacerbation and had prolonged remission.

The complex therapy revealed to be more effective than drug therapy and psychotherapy separately. Combining SSRI antidepressants with cognitive psychotherapy helps clinicians to prolong remissions and to decrease the exacerbation rate at adolescents with anxiety-depressive disorders.