Skip to main content Accessibility help
×
Home

Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder

  • Adriana Palacios (a1), Patricia Canto (a1) (a2), María Elena Tejeda (a1), Sylvana Stephano (a2), Hassell Luján (a1), Eduardo García-García (a2), David Rojano-Mejía (a3) and Juan Pablo Méndez (a1) (a2)...

Abstract

Background:

The aim of this study was to investigate if Mexican-Mestizo individuals with obesity, with or without binge eating disorder (BED), exhibited mutations or other type of genetic variants in the sequence of ANKK1.

Subjects and methods:

Fifty unrelated individuals (21–53 years of age) with obesity, of Mexican-Mestizo ethnic origin were included; 25 of them had BED and 25 presented obesity without BED. The diagnosis of BED was based on criteria proposed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Besides, we also analyzed 100 individuals with normal body mass index. DNA from blood leukocytes was amplified by the polymerase chain reaction and all exons of ANKK1 were sequenced.

Results:

After ANKK1 sequencing we did not find any mutations; however, we observed various polymorphisms. One polymorphism, rs4938013 in exon 2 showed an association with obesity, whilst rs1800497 (also known as Taq1A) in exon 8, showed an association with BED (P = 0.020). Remarkable, for this study, the number of individuals for both polymorphisms for and additive model was sufficient to derive strong statistical power (80%, with a P < 0.05).

Conclusions:

To our knowledge, this constitutes the first report where the complete sequences of ANKK1 has been analyzed in individuals with obesity, with or without BED. No mutations were found; however, one polymorphism was associated with obesity, with or without BED, and another one was associated with BED.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author at: Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico. E-mail address: jpmb@unam.mx (J.P. Méndez).

References

Hide All
[1]Encuesta Nacional de Salud y Nutrición de Medio Camino (ENSANUT MC) Cuernavaca 2016, Instituto Nacional de Salud Pública Mexico.
[2]Chouinard, VAPingali, SMChouinard, GHenderson, DCMallya, SGCypess, AM et al. Factors associated with overweight and obesity in schizophrenia, schizoaffective and bipolar disorders. Psychiatry Res 2016; 237:304–10.
[3]Segura-Garcia, CCaroleo, MRania, MBarbuto, ESinopoli, FAloi, M et al. Binge Eating Disorder and Bipolar Spectrum disorders in obesity: psychopathological and eating behaviors differences according to comorbidities. J Affect Disord 2017; 208:424–30.
[4]Pagoto, SBodenlos, JSKantor, LGitkind, MCurtin, CMa, YAssociation of major depression and binge eating disorder with weight loss in a clinical setting. Obesity 2007; 15:2557–9.
[5]American Psychiatric Association Diagnostic and statistical manual of mental disorders fifth edition2013, American Psychiatric Association Washington, DC.
[6]Kessler, RCBerglund, PAChiu, WTDeitz, ACHudson, JIShahly, V et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry 2013; 7:904–14.
[7]Grilo, CMWhite, MABarnes, RDMasheb, RMPsychiatric disorder comorbidity and correlates in an ethnically diverse sample of obese patients with binge eating disorder in primary care settings. Compr Psychiatry 2013; 54:209–16.
[8]Reichborn-Kjennerud, TBulik, CTambs, KHarris, JGenetic and environmental influences on binge eating in the absence of compensatory behaviours: a population-based twin study. Int J Eat Disord 2004; 36:307–14.
[9]Javaras, KNLaird, NMReichborn-Kjennerud, TBulik, CMPope, HG JrHudson, JIFamiliality and heritability of binge eating disorder: results of a case-control family study and a twin study. Int J Eat Disord 2008; 41:174–9.
[10]Hinney, AVolckmar, ALGenetics of eating disorders. Curr Psychiatry Rep 2013; 15:423.
[11]Davis, CALevitan, RDReid, CCarter, JCKaplan, ASPatte, KA et al. Dopamine for “wanting” and opioids for “liking”: a comparison of obese adults with and without binge eating. Obesity (Silver Spring, Md) 2009; 17:1220–5.
[12]Samek, DRBailey, JHill, KGWilson, SLee, SKeyes, MA et al. A Test-replicate approach to candidate gene research on addiction and externalizing disorders: a collaboration across five Longitudinal Studies. Behav Genet 2016; 46:608–26.
[13]Neville, MJJohnstone, ECWalton, RTIdentification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 2004; 23:540–5.
[14]Hoenicka, JQuinones-Lombrana, AEspana-Serrano, LAlvira-Botero, XKremer, LPerez-Gonzalez, R et al. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Biol Psychiatry 2010; 67:311.
[15]Felsted, JARen, XChouinard-Decorte, FSmall, DMGenetically determined differences in brain response to a primary food reward. J Neurosci 2010; 30:2428–32.
[16]Davis, CLevitan, RDKaplan, ASCarter, JReid, CCurtis, C et al. Reward sensitivity and the D2 dopamine receptor gene: a case-control study of binge eating disorder. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:620–8.
[17]Davis, CLevitan, RDYilmaz, ZKaplan, ASCarter, JCKennedy, JLBinge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. Prog Neuropsychopharmacol Biol Psychiatry 2012; 38:328–35.
[18]Yeh, JTrang, AHenning, SMWilhalme, HCarpenter, CHeber, D et al. Food cravings. Food cravings, food addiction, and a dopamine-resistant (DRD2 A1) receptor polymorphism in Asian American college students. Asia Pac J Clin Nutr 2016; 25:424–9.
[19]Gorodezky, CAlaez, CVázquez-García, MNde la Rosa, GInfante, EBalladares, S et al. The genetic structure of Mexican Mestizos of different locations: tracking back their origins through MHC genes, blood group systems, and microsatellites. Hum Immunol 2001; 62:979–91.
[20]Miller, SADykes, DDPolesky, HFA simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
[21]Narayanaswami, VThompson, ACCassis, LABardo, MTDwoskin, LPDiet induced obesity: dopamine transporter function, impulsivity and motivation. Int J Obes 2013; 37:1095–103.
[22]Blum, KThanos, PKGold, MSDopamine and glucose, obesity, and reward deficiency syndrome. Front Psychol 2014; 5:919.
[23]Kessler, RMHutson, PHHerman, BKPotenza, MNThe neurobiological basis of binge-eating disorder. Neurosci Biobehav Rev 2016; 63:223–38.
[24]Steiger, HThaler, LGauvin, LJoober, RLabbe, AIsrael, M et al. Epistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances. J Psychiatr Res 2016; 77:814.
[25]Jönsson, EGNöthen, MMGrünhage, FFarde, LNakashima, YPropping, P et al. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol Psychiatry 1999; 4:290–6.
[26]Munafò, MRMatheson, IJFlint, JAssociation of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case–control studies and evidence of publication bias. Mol Psychiatry 2007; 12:454–61.
[27]Panduro, ARamos-Lopez, OCampollo, OZepeda-Carrillo, EAGonzalez-Aldaco, KTorres-Valadez, R et al. High frequency of the DRD2/ANKK1 A1 allele in Mexican Native Amerindians and Mestizos and its association with alcohol consumption. Drug Alcohol Depend 2017; 172:6672.
[28]Deng, XDJiang, HMa, YGao, QZhang, BMu, B et al. Association between DRD2/ANKK1 TaqIA polymorphism and common illicit drug dependence: evidence from a meta-analysis. Hum Immunol 2015; 76:4251.
[29]Noble, EPBlum, KRitchie, TMontgomery, ASheridan, PJAllelic association of the D2 dopamine receptor gene with receptor binding characteristics in alcoholism. Arch Gen Psychiatry 1991; 48:648–54.
[30]Lisker, RRamirez, EPerez-Briceño, RGranados, JBabinsky, VGene frequencies and admixture estimates in four Mexican urban centers. Hum Biol 1990; 62:791801.
[31]Lee, STRyu, SKim, SRKim, MJKim, SKim, JW et al. Association study of 27 annotated genes for clozapine pharmacogenetics validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. Clin Psychopharmacol 2012; 32:441–8.
[32]Yang, ZPAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol 2007; 24:1586–91.
[33]Plotkin, JBKudla, GSynonymous but not the same: the causes and consequences of codon bias. Nat Rev Genet 2011; 12:3242.
[34]Komar, AAThe Yin and Yang of codon usage. Hum Mol Genet 2016; 25:R7785.
[35]Saunders, RDeane, CMSynonymous codon usage influences the local protein structure observed. Nucleic Acids Res 2010; 38:6719–28.
[36]Drummond, DAWilke, COMistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell 2008; 134:341–52.
[37]Presnyak, VAlhusaini, NChen, YHMartin, SMorris, NKline, N et al. Codon optimality is a major determinant of mRNA stability. Cell 2015; 160:1111–24.
[38]Stergachis, ABHaugen, EShafer, AFu, WVernot, BReynolds, A et al. Exonic transcription factor binding directs codon choice and affects protein evolution. Science 2013; 342:1367–72.

Keywords

Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder

  • Adriana Palacios (a1), Patricia Canto (a1) (a2), María Elena Tejeda (a1), Sylvana Stephano (a2), Hassell Luján (a1), Eduardo García-García (a2), David Rojano-Mejía (a3) and Juan Pablo Méndez (a1) (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Complete sequence of the ANKK1 gene in Mexican-Mestizo individuals with obesity, with or without binge eating disorder

  • Adriana Palacios (a1), Patricia Canto (a1) (a2), María Elena Tejeda (a1), Sylvana Stephano (a2), Hassell Luján (a1), Eduardo García-García (a2), David Rojano-Mejía (a3) and Juan Pablo Méndez (a1) (a2)...
Submit a response

Comments

We encountered an error trying to retrieve Comments for this article. Please try again or contact Customer Services

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *