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Comparison of risperidone response rate between different CYP2D6 metabolisers

Published online by Cambridge University Press:  16 April 2020

R. Barteček
Affiliation:
Department of Psychiatry, Faculty of Medicine, Masaryk University and Faculty Hospital Brno-Bohunice, Brno, Czech Republic
J. Juřica
Affiliation:
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
J. Zrůstová
Affiliation:
Department of Medical Genetics, Faculty Hospital Brno, Brno, Czech Republic
T. Kašpárek
Affiliation:
Department of Psychiatry, Faculty of Medicine, Masaryk University and Faculty Hospital Brno-Bohunice, Brno, Czech Republic
A. Žourková
Affiliation:
Department of Psychiatry, Faculty of Medicine, Masaryk University and Faculty Hospital Brno-Bohunice, Brno, Czech Republic

Abstract

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Introduction

Risperidone is an antipsychotic used as the first-line treatment of schizophrenia. Risperidone is metabolised by enzyme CYP2D6. Activity of this enzyme can be predicted by genotypization.

Objectives

To explore the possibility of different response rate to risperidone in first-episode schizophrenia patients with different CYP2D6 genotype.

Aim

To asses the utility of CYP2D6 pharmacogenetic testing in patients with schizophrenia treated with risperidone.

Methods

CYP2D6 genotype was assessed in 22 first-episode schizophrenic patients by use of automatic sequencing of DNA isolated from peripheral leukocytes. PANSS score was assessed every week of treatment until the change in medication or patient release.

Response was defined as at least 30% reduction in total PANSS. Differences in response rate between groups were tested by Fisher's exact test.

Results

10 CYP2D6 extensive metabolisers (EM), 8 intermediate metabolisers (IM) and 4 poor metabolisers (PM) were identified. Criteria for response met 4 EM, 4 IM and 1 PM. Differences in response rate between groups were not statistically significant.

Conclusions

Although group of IM had higher response rate than EM and PM, differences in response rate did not reach statistical significance. Further differences may be found by extending the sample size. An useful approach would be also to examine differences in occurrence of adverse effects and subjective tolerance of the treatment.

Acknowledgement

The study was supported by the grant of Czech Ministry of Health No. NS 9676-4/2008.

Type
P02-451
Copyright
Copyright © European Psychiatric Association 2011
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