The lecture gives an up-dated overview on comorbidity rates in affective disorders and personality disorders. The data will be presented from two perspectives: First of all, comorbidities with affective disorders in patients with personality disorders will be shown, differentiating rates for personality disorder clusters and for single disorders. Complementary, co-occurences with personality disorders for patients with affective disorders will be presented, differentiating between unipolar and bipolar affective disorders. Moreover, the relevance of comorbidities for treatment and course of personality disorders will be discussed. Conceptual problems concerning the differentiation of specific personality disorders and affective disorders (e.g. borderline personality disorder vs. bipolar spectrum disorders or depressive personality disorder vs. dysthymia) will also be reported.